PKC delta Antibody (G-9): sc-8402

PKC δ Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PKC delta of mouse, rat, and human origin by WB, IP, IF, IHCP, and ELISA. PKC δ (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, HRP, PE, FITC, and multiple Alexa Fluor® conjugates. PKC delta plays a crucial role in cellular signaling pathways, particularly in the regulation of apoptosis and cell survival, making PKC delta an important target for cancer research and therapeutic interventions. Located primarily in the cytoplasm and translocating to the membrane upon activation, PKC delta′s ability to modulate various signaling cascades is vital for maintaining cellular homeostasis and responding to extracellular stimuli. PKC delta′s unique structure, characterized by a C1 domain that binds diacylglycerol and a C2 domain that interacts with phospholipids, allows for precise regulation of activity in response to cellular signals. Understanding PKC delta′s localization and function can provide insights into PKC delta′s role in diseases such as cancer, where dysregulation of apoptosis and cell proliferation is often observed.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PKC delta Antibody (G-9) References:

1. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.  |  Osada, S., et al. 1992. Mol Cell Biol. 12: 3930-8. PMID: 1508194
2. Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC.  |  Ohno, S., et al. 1991. Adv Enzyme Regul. 31: 287-303. PMID: 1877391
3. Expression and characterization of protein kinase C-delta.  |  Olivier, AR. and Parker, PJ. 1991. Eur J Biochem. 200: 805-10. PMID: 1915352
4. The roles of PKC-δ and PKC-ε in myocardial ischemia/reperfusion injury.  |  Chen, L., et al. 2021. Pharmacol Res. 170: 105716. PMID: 34102229
5. Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective.  |  Miao, LN., et al. 2022. Front Cardiovasc Med. 9: 816369. PMID: 35242825
6. Inhibition of PKC-δ reduce rhabdomyolysis-induced acute kidney injury.  |  Wu, D., et al. 2022. J Cell Mol Med. 26: 3243-3253. PMID: 35502493
7. Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice.  |  Wang, D., et al. 2024. Cell Death Discov. 10: 314. PMID: 38972937
8. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.  |  Takai, Y., et al. 1979. J Biol Chem. 254: 3692-5. PMID: 438153
9. Turnover of inositol phospholipids and signal transduction.  |  Nishizuka, Y. 1984. Science. 225: 1365-70. PMID: 6147898
10. The role of protein kinase C in cell surface signal transduction and tumour promotion.  |  Nishizuka, Y. Nature. 308: 693-8. PMID: 6232463
11. Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.  |  Kikkawa, U., et al. 1983. J Biol Chem. 258: 11442-5. PMID: 6311812
12. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.  |  Castagna, M., et al. 1982. J Biol Chem. 257: 7847-51. PMID: 7085651

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKC delta Antibody (G-9) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-PKC delta Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKC delta Antibody (G-9) Specifications

Alternate Product Name: PRKCD

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 657-673

Epitope Target: PKC δ

Epitope Species: rat

Product Reactivity/Detection: PKC δ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for PKC delta Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred PKC antibody is PKC Antibody (A-3): sc-17769.