PKC delta Antibody (G-9): sc-8402
- PKC delta Antibody (G-9) is a mouse monoclonal IgG1 κ PKC delta antibody, cited in 32 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 657-673 at the C-terminus of PKC δ of rat origin
- PKC delta Antibody (G-9) is recommended for detection of PKC δ of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PKC delta Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for PKC delta Antibody (G-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with PKC delta Antibody (G-9) (see ordering information below).
PKC δ Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PKC delta of mouse, rat, and human origin by WB, IP, IF, IHCP, and ELISA. PKC δ (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, HRP, PE, FITC, and multiple Alexa Fluor® conjugates. PKC delta plays a crucial role in cellular signaling pathways, particularly in the regulation of apoptosis and cell survival, making PKC delta an important target for cancer research and therapeutic interventions. Located primarily in the cytoplasm and translocating to the membrane upon activation, PKC delta′s ability to modulate various signaling cascades is vital for maintaining cellular homeostasis and responding to extracellular stimuli. PKC delta′s unique structure, characterized by a C1 domain that binds diacylglycerol and a C2 domain that interacts with phospholipids, allows for precise regulation of activity in response to cellular signals. Understanding PKC delta′s localization and function can provide insights into PKC delta′s role in diseases such as cancer, where dysregulation of apoptosis and cell proliferation is often observed.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PKC delta Antibody (G-9) References:
- A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. | Osada, S., et al. 1992. Mol Cell Biol. 12: 3930-8. PMID: 1508194
- Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. | Ohno, S., et al. 1991. Adv Enzyme Regul. 31: 287-303. PMID: 1877391
- Expression and characterization of protein kinase C-delta. | Olivier, AR. and Parker, PJ. 1991. Eur J Biochem. 200: 805-10. PMID: 1915352
- The roles of PKC-δ and PKC-ε in myocardial ischemia/reperfusion injury. | Chen, L., et al. 2021. Pharmacol Res. 170: 105716. PMID: 34102229
- Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective. | Miao, LN., et al. 2022. Front Cardiovasc Med. 9: 816369. PMID: 35242825
- Inhibition of PKC-δ reduce rhabdomyolysis-induced acute kidney injury. | Wu, D., et al. 2022. J Cell Mol Med. 26: 3243-3253. PMID: 35502493
- Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice. | Wang, D., et al. 2024. Cell Death Discov. 10: 314. PMID: 38972937
- Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. | Takai, Y., et al. 1979. J Biol Chem. 254: 3692-5. PMID: 438153
- Turnover of inositol phospholipids and signal transduction. | Nishizuka, Y. 1984. Science. 225: 1365-70. PMID: 6147898
- The role of protein kinase C in cell surface signal transduction and tumour promotion. | Nishizuka, Y. Nature. 308: 693-8. PMID: 6232463
- Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. | Kikkawa, U., et al. 1983. J Biol Chem. 258: 11442-5. PMID: 6311812
- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. | Castagna, M., et al. 1982. J Biol Chem. 257: 7847-51. PMID: 7085651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKC delta Antibody (G-9) | sc-8402 | 200 µg/ml | $322.00 | |||
PKC delta Antibody (G-9): m-IgG1 BP-HRP Bundle | sc-531633 | 200 µg Ab; 20 µg BP | $361.00 | |||
PKC delta Antibody (G-9) AC | sc-8402 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PKC delta Antibody (G-9) HRP | sc-8402 HRP | 200 µg/ml | $322.00 | |||
PKC delta Antibody (G-9) FITC | sc-8402 FITC | 200 µg/ml | $336.00 | |||
PKC delta Antibody (G-9) PE | sc-8402 PE | 200 µg/ml | $349.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 488 | sc-8402 AF488 | 200 µg/ml | $364.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 546 | sc-8402 AF546 | 200 µg/ml | $364.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 594 | sc-8402 AF594 | 200 µg/ml | $364.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 647 | sc-8402 AF647 | 200 µg/ml | $364.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 680 | sc-8402 AF680 | 200 µg/ml | $364.00 | |||
PKC delta Antibody (G-9) Alexa Fluor® 790 | sc-8402 AF790 | 200 µg/ml | $364.00 | |||
PKC delta (G-9) Neutralizing Peptide | sc-8402 P | 100 µg/0.5 ml | $69.00 |