PKA Iβ reg Antibody (QR-7): sc-100414

PKA Iβ reg Antibody (QR-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects PKA Iβ reg in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PKA Iβ reg antibody (QR-7) is available in a non-conjugated form, allowing for versatile experimental use. The PKA Iβ regulatory subunit plays a crucial role in regulating the cAMP-dependent protein kinase (PKA) pathway, which mediates cellular responses to external stimuli. PKA Iβ reg is primarily located in the cytoplasm, forming a tetrameric holoenzyme with two regulatory and two catalytic subunits. The spatial organization of PKA enables rapid and localized signaling in response to cAMP levels, facilitating processes such as gene transcription, metabolism regulation, and ion transport. Upon activation by cAMP, PKA Iβ reg undergoes a conformational change that releases active catalytic subunits, enabling nuclear translocation and phosphorylation of key transcription factors like cAMP response element binding protein (CREB). This phosphorylation event activates genes involved in various physiological processes, highlighting PKA Iβ reg′s significance in cellular signaling and function.

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PKA Iβ reg Antibody (QR-7) References:

1. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.  |  Beebe, SJ., et al. 1990. Mol Endocrinol. 4: 465-75. PMID: 2342480
2. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.  |  Gonzalez, GA. and Montminy, MR. 1989. Cell. 59: 675-80. PMID: 2573431
3. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.  |  Maldonado, F. and Hanks, SK. 1988. Nucleic Acids Res. 16: 8189-90. PMID: 2843813
4. Phosphorylation-dephosphorylation of enzymes.  |  Krebs, EG. and Beavo, JA. 1979. Annu Rev Biochem. 48: 923-59. PMID: 38740
5. Activation of protein kinase by physiological concentrations of cyclic AMP.  |  Beavo, JA., et al. 1974. Proc Natl Acad Sci U S A. 71: 3580-3. PMID: 4372627
6. Signal transduction through the cAMP-dependent protein kinase.  |  Meinkoth, JL., et al. 1993. Mol Cell Biochem. 127-128: 179-86. PMID: 7935349
7. Transcription factors. CREB takes CBP to tango.  |  Nordheim, A. 1994. Nature. 370: 177-8. PMID: 8028657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKA Iβ reg Antibody (QR-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-PKA Iβ reg Antibody (QR-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKA Iβ reg Antibody (QR-7) Specifications

Alternate Product Name: PKA Iβ reg

Product Clone Name: QR-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-91

Epitope Target: PKA Iβ reg

Epitope Species: human

Product Reactivity/Detection: PKA Iβ reg

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PKA Iβ reg Antibody (QR-7): N/A