PITSLRE Antibody (B-9): sc-377296

PITSLRE Antibody (B-9) is a mouse monoclonal IgM antibody that detects PITSLRE protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PITSLRE antibody (B-9) is available as the non-conjugated form. PITSLRE β1 protein, a member of the cyclin-dependent kinase (Cdk) family, plays a crucial role in regulating apoptosis, a vital process for maintaining cellular homeostasis and eliminating damaged cells. PITSLRE β1 protein induces apoptosis following low levels of ectopic expression, highlighting its importance in cellular response mechanisms. An amino terminal deletion mutant of PITSLRE β1 that retains catalytic and carboxy terminal domains can also induce apoptosis, while other mutants lacking histone H1 kinase activity or other Cdk family members do not elicit this response. The PITSLRE subfamily consists of ten isoforms, with nomenclature based on the conserved PSTAIRE box region of Cdc2 p34, and specific isoforms produced depend on PITSLRE genes involved, designated as α, β, or γ. Certain isoforms, such as PITSLRE α1 found in T cells and PITSLRE β1 expressed in B cells and brain, exhibit cell-type specificity, while others are expressed more broadly across various tissues. PITSLRE (B-9) antibody is an essential tool for researchers studying the intricate roles of PITSLRE in apoptosis and its implications in health and disease.

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PITSLRE Antibody (B-9) References:

1. PITSLRE p110 protein kinases associate with transcription complexes and affect their activity.  |  Trembley, JH., et al. 2002. J Biol Chem. 277: 2589-96. PMID: 11709559
2. A family of human cdc2-related protein kinases.  |  Meyerson, M., et al. 1992. EMBO J. 11: 2909-17. PMID: 1639063
3. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.  |  Petretti, C., et al. 2006. EMBO Rep. 7: 418-24. PMID: 16462731
4. Mechanisms and functions of cell death.  |  Ellis, RE., et al. 1991. Annu Rev Cell Biol. 7: 663-98. PMID: 1809356
5. Programmed cell death in the immune system.  |  Cohen, JJ. 1991. Adv Immunol. 50: 55-85. PMID: 1950799
6. Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.  |  Bunnell, BA., et al. 1990. Proc Natl Acad Sci U S A. 87: 7467-71. PMID: 2217177
7. PITSLRE protein kinase activity is associated with apoptosis.  |  Lahti, JM., et al. 1995. Mol Cell Biol. 15: 1-11. PMID: 7528324
8. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.  |  Lahti, JM., et al. 1994. Nat Genet. 7: 370-5. PMID: 7920654
9. Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.  |  Xiang, J., et al. 1994. J Biol Chem. 269: 15786-94. PMID: 8195233
10. Programmed cell death and the control of cell survival: lessons from the nervous system.  |  Raff, MC., et al. 1993. Science. 262: 695-700. PMID: 8235590
11. Bcl-2 and the regulation of programmed cell death.  |  Reed, JC. 1994. J Cell Biol. 124: 1-6. PMID: 8294493
12. Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.  |  Beyaert, R., et al. 1997. J Biol Chem. 272: 11694-7. PMID: 9115219

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PITSLRE Antibody (B-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PITSLRE Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PITSLRE Antibody (B-9) Specifications

Alternate Product Name: PITSLRE

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 749-775

Epitope Target: PITSLRE A

Epitope Species: human

Product Reactivity/Detection: PITSLRE A and PITSLRE B of human origin and PITSLRE of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PITSLRE Antibody (B-9): P: Blocking Peptide