PIPOX Antibody (E-7): sc-376914
- PIPOX Antibody (E-7) is a mouse monoclonal IgG1 κ PIPOX antibody provided at 200 µg/ml
- raised against amino acids 176-345 mapping near the C-terminus of PIPOX of human origin
- PIPOX Antibody (E-7) is recommended for detection of PIPOX of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PIPOX Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PIPOX Antibody (E-7) for WB applications. This reagent is now offered in a bundle with PIPOX Antibody (E-7) (see ordering information below).
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PIPOX Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PIPOX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PIPOX antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PIPOX, also known as pipecolic acid oxidase, is a 390 amino acid enzyme that plays a crucial role in the metabolism of amino acids, specifically catalyzing the degradation of sarcosine, L-pipecolic acid, and L-proline using flavin adenine dinucleotide as a cofactor. This enzymatic activity is vital for maintaining cellular homeostasis and energy balance, as PIPOX helps regulate the levels of these metabolites, which can influence various metabolic pathways. PIPOX is localized in the peroxisome, an organelle responsible for lipid metabolism and the detoxification of reactive oxygen species, highlighting PIPOX′s importance in cellular health and function. The gene encoding PIPOX is located on human chromosome 17, a region that is significant due to its association with key tumor suppressor genes such as p53 and BRCA1, both of which are critical for maintaining genomic stability and preventing cancer. PIPOX′s proper functioning may therefore have implications for understanding metabolic disorders and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PIPOX Antibody (E-7) References:
- L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. | Dodt, G., et al. 2000. Biochem J. 345 Pt 3: 487-94. PMID: 10642506
- Molecular cloning and expression of human L-pipecolate oxidase. | IJlst, L., et al. 2000. Biochem Biophys Res Commun. 270: 1101-5. PMID: 10772957
- Enzyme cytochemical localization of sarcosine oxidase activity in the liver and kidney of several mammals. | Chikayama, M., et al. 2000. Histochem Cell Biol. 113: 489-95. PMID: 10933225
- The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases. | Dodt, G., et al. 2000. Cell Biochem Biophys. 32 Spring: 313-6. PMID: 11330064
- Susceptibility to breast cancer: hereditary syndromes and low penetrance genes. | Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139
- Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase. | Reuber, BE., et al. 1997. J Biol Chem. 272: 6766-76. PMID: 9045710
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIPOX Antibody (E-7) | sc-376914 | 200 µg/ml | $322.00 | |||
PIPOX Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-526062 | 200 µg Ab; 10 µg BP | $361.00 | |||
PIPOX Antibody (E-7) AC | sc-376914 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PIPOX Antibody (E-7) HRP | sc-376914 HRP | 200 µg/ml | $322.00 | |||
PIPOX Antibody (E-7) FITC | sc-376914 FITC | 200 µg/ml | $336.00 | |||
PIPOX Antibody (E-7) PE | sc-376914 PE | 200 µg/ml | $349.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 488 | sc-376914 AF488 | 200 µg/ml | $364.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 546 | sc-376914 AF546 | 200 µg/ml | $364.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 594 | sc-376914 AF594 | 200 µg/ml | $364.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 647 | sc-376914 AF647 | 200 µg/ml | $364.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 680 | sc-376914 AF680 | 200 µg/ml | $364.00 | |||
PIPOX Antibody (E-7) Alexa Fluor® 790 | sc-376914 AF790 | 200 µg/ml | $364.00 |