Molecular structure of Pimozide, CAS Number: 2062-78-4
Pimozide (CAS 2062-78-4)
See product citations (3)
Alternate Names:
Orap; Opiran; Neoperidole; Pimozidum
Application:
Pimozide is a D2DR, SR-7, and calcium channel protein inhbitor
CAS Number:
2062-78-4
Molecular Weight:
461.55
Molecular Formula:
C28H29F2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pimozide is widely used in research focusing on its role as a dopamine receptor antagonist. In neuroscience, it is employed to study changes in neurotransmitter systems, particularly dopamine, and how these changes affect behavior and neurological conditions. Pimozide is also used in studies to understand the neurobiological basis of disorders related to dopamine dysregulation. Additionally, it serves as a tool to explore the mechanisms of action of dopamine in various cognitive processes such as learning and memory. In biochemistry, research on Pimozide includes investigating its binding affinity and effect on dopamine receptors, which helps in understanding the receptor′s role in signal transduction pathways.
Pimozide (CAS 2062-78-4) References
- Pimozide suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling pathway. | Ren, Y., et al. 2018. Life Sci. 209: 267-273. PMID: 30107167
- USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis. | Ma, A., et al. 2019. Oncogene. 38: 2405-2419. PMID: 30531833
- Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. | Huhn, M., et al. 2019. Lancet. 394: 939-951. PMID: 31303314
- Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species. | Kim, U., et al. 2019. Front Pharmacol. 10: 1517. PMID: 32009948
- Suppressing STAT5 signaling affects osteosarcoma growth and stemness. | Subramaniam, D., et al. 2020. Cell Death Dis. 11: 149. PMID: 32094348
- Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation. | Al Batran, R., et al. 2020. Cell Metab. 31: 909-919.e8. PMID: 32275862
- The antipsychotic drug pimozide inhibits IgE-mediated mast cell degranulation and migration. | Hou, YB., et al. 2020. Int Immunopharmacol. 84: 106500. PMID: 32311669
- Pimozide Suppresses the Growth of Brain Tumors by Targeting STAT3-Mediated Autophagy. | Ranjan, A., et al. 2020. Cells. 9: PMID: 32971907
- Pimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5/cyclin D1 and STAT5/Bcl‑xL signaling pathways. | Xiao, Z., et al. 2021. Int J Mol Med. 47: 113-124. PMID: 33155660
- Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. | Meyer, N., et al. 2021. Autophagy. 17: 3424-3443. PMID: 33461384
- The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells. | Ishikawa, C. and Mori, N. 2021. Eur J Pharmacol. 908: 174373. PMID: 34303663
- Pimozide inhibits the growth of breast cancer cells by alleviating the Warburg effect through the P53 signaling pathway. | Li, J., et al. 2022. Biomed Pharmacother. 150: 113063. PMID: 35658233
- Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain. | Kasanami, Y., et al. 2022. Eur J Med Chem. 243: 114716. PMID: 36075145
- P-Glycoprotein-Mediated Pharmacokinetic Interactions Increase Pimozide hERG Channel Inhibition. | Morishita, H., et al. 2022. J Pharm Sci. 111: 3411-3416. PMID: 36181876
- Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. | Roth, BL., et al. 1994. J Pharmacol Exp Ther. 268: 1403-10. PMID: 7908055
Inhibitor of:
Brn-3b, Calcium Channel Protein, CALML4, calmodulin, CatSperδ, CB1, D2DR, Dopamine, DUB1, HTLV-1 p24, IFN-τ, IL-3R, KIAA1958, OTTMUSG00000011262, OTTMUSG00000011265, PCP-4, Placental lactogen I, progonadoliberin I, SOCS-4, Sox-21, SR-7, Stat1, Stat5a, Stat5b, T-type Ca++ CP α1I, T-type calcium channel α1G, T-type calcium channel α1H, T-type calcium channel α1I, TAAR7B, TALK-1, USP1, USP18, USP9X, USPL1, Vmn2r121, and Vmn2r34.Activator of:
DRD1a, eIF3θ, ISG20, MBNL1, PLP-L, and USP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pimozide, 100 mg | sc-203662 | 100 mg | $102.00 |