PIG3 Antibody (10A2): sc-65227
- PIG3 Antibody (10A2) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant PIG-3 protein of human origin
- recommended for detection of PIG3 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PIG3 Antibody (10A2). This work is in progress.
QUICK LINKS
SEE ALSO...
PIG3 Antibody (10A2) is a mouse monoclonal IgG1 antibody that detects PIG3 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). PIG3, a member of the p53-induced gene family, plays a crucial role in cellular responses to oxidative stress and is involved in the tumor suppressor activity of p53. PIG3 is primarily localized in the cytoplasm, where induction occurs in both primary and transformed cell cultures following exposure to genotoxic agents. PIG3 induction is notably p53-dependent and exhibits delayed kinetics compared to other downstream targets of p53, highlighting a unique regulatory role in the cellular stress response. PIG3 interacts with caspase-8, serving as a key regulatory element in p53-dependent transcriptional deregulation by initiating the caspase cascade and promoting mitochondrial breakdown. This interaction underscores PIG3′s importance in the intricate network of cellular signaling pathways that respond to DNA damage and oxidative stress, making PIG3 a valuable marker for studying p53 activation and implications in cancer biology. Anti-PIG3 antibody (10A2) serves as an essential tool for researchers investigating the dynamics of p53 signaling and impact on cellular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PIG3 Antibody (10A2) References:
- p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. | Flatt, PM., et al. 2000. Cancer Lett. 156: 63-72. PMID: 10840161
- The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage. | Lee, JH., et al. 2010. Oncogene. 29: 1431-50. PMID: 20023697
- PIG3 functions in DNA damage response through regulating DNA-PKcs homeostasis. | Li, B., et al. 2013. Int J Biol Sci. 9: 425-34. PMID: 23678292
- BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner. | Zhang, W., et al. 2015. Oncotarget. 6: 7608-18. PMID: 25797244
- PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway. | Xu, J., et al. 2015. Oncol Rep. 34: 1424-30. PMID: 26133772
- Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells. | Chen, G., et al. 2016. Oncotarget. 7: 27176-84. PMID: 27029070
- PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients. | Li, M., et al. 2017. J Exp Clin Cancer Res. 36: 39. PMID: 28259183
- The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells. | Park, SJ., et al. 2017. Korean J Physiol Pharmacol. 21: 267-273. PMID: 28280421
- PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination. | Jin, M., et al. 2017. Biomol Ther (Seoul). 25: 396-403. PMID: 28605833
- PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis. | Chu, Y., et al. 2018. J Biol Regul Homeost Agents. 32: 1185-1189. PMID: 30334411
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIG3 Antibody (10A2) | sc-65227 | 100 µg/ml | $322.00 |