PI 3-kinase p110γ Antibody (D-12): sc-166365

PI 3-kinase p110γ Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects PI 3-kinase p110 gamma (PI3Kγ) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PI3Kγ (D-12) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The phosphatidylinositol 3-kinase pathway plays a crucial role in cellular functions such as growth, proliferation, and survival, with PI3Kγ being particularly important in immune responses. PI3Kγ is primarily expressed in leukocytes and is activated by G protein-coupled receptors, which is vital for mediating signaling pathways that lead to cellular responses during immune activation. Understanding PI3Kγ function is essential, as dysregulation can contribute to various diseases, including cancer and autoimmune disorders. Anti-PI3Kγ antibody (D-12) specificity for PI3Kγ allows researchers to investigate unique roles in these processes, making PI3Kγ (D-12) monoclonal antibody a valuable tool for studying immune cell signaling and function.

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PI 3-kinase p110γ Antibody (D-12) References:

1. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.  |  Hiles, ID., et al. 1992. Cell. 70: 419-29. PMID: 1322797
2. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.  |  Otsu, M., et al. 1991. Cell. 65: 91-104. PMID: 1707345
3. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.  |  Skolnik, EY., et al. 1991. Cell. 65: 83-90. PMID: 1849461
4. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.  |  Stoyanov, B., et al. 1995. Science. 269: 690-3. PMID: 7624799
5. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.  |  Hu, P., et al. 1993. Mol Cell Biol. 13: 7677-88. PMID: 8246984
6. P110delta, a novel phosphoinositide 3-kinase in leukocytes.  |  Vanhaesebroeck, B., et al. 1997. Proc Natl Acad Sci U S A. 94: 4330-5. PMID: 9113989

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PI 3-kinase p110γ Antibody (D-12) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-PI 3-kinase p110γ Antibody (D-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PI 3-kinase p110γ Antibody (D-12) Specifications

Alternate Product Name: PI3K p110 gamma

Product Clone Name: D-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 32-58

Epitope Target: PI 3-kinase p110γ

Epitope Species: human

Product Reactivity/Detection: PI 3-kinase p110γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for PI 3-kinase p110γ Antibody (D-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin