PI 3-kinase p110δ Antibody (A-8): sc-55589

PI 3-kinase p110δ Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects PI 3-kinase p110 delta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p110δ (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The phosphatidylinositol 3-kinase (PI 3-kinase) pathway plays a crucial role in cellular functions such as growth, proliferation, and survival, with PI 3-kinase p110δ being particularly important in immune responses. PI 3-kinase p110δ is predominantly expressed in leukocytes, where PI 3-kinase p110δ regulates various signaling pathways essential for immune cell activation and differentiation. PI 3-kinase p110δ′s ability to autophosphorylate and modulate lipid kinase activity is vital for maintaining proper immune function, as dysregulation can lead to immune disorders and has been implicated in various diseases, including cancer and autoimmune conditions. Understanding PI 3-kinase p110δ interactions and functions is essential for developing targeted therapies that can modulate immune responses effectively.

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PI 3-kinase p110δ Antibody (A-8) References:

1. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.  |  Hiles, ID., et al. 1992. Cell. 70: 419-29. PMID: 1322797
2. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.  |  Otsu, M., et al. 1991. Cell. 65: 91-104. PMID: 1707345
3. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.  |  Skolnik, EY., et al. 1991. Cell. 65: 83-90. PMID: 1849461
4. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.  |  Soond, DR., et al. 2010. Blood. 115: 2203-13. PMID: 20081091
5. Phosphoinositide 3-kinase delta (PI3KΔ) in leukocyte signaling and function.  |  Fung-Leung, WP. 2011. Cell Signal. 23: 603-8. PMID: 20940048
6. p37Δ is a new isoform of PI3K p110Δ that increases cell proliferation and is overexpressed in tumors.  |  Fransson, S., et al. 2012. Oncogene. 31: 3277-86. PMID: 22020336
7. Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.  |  Law, AJ., et al. 2012. Proc Natl Acad Sci U S A. 109: 12165-70. PMID: 22689948
8. Activated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype.  |  Zhao, P., et al. 2024. Pediatr Rheumatol Online J. 22: 24. PMID: 38287413
9. A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular Proliferation.  |  Martucci, NJ., et al. 2024. Am J Pathol. 194: 1511-1527. PMID: 38705383
10. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.  |  Stoyanov, B., et al. 1995. Science. 269: 690-3. PMID: 7624799
11. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.  |  Hu, P., et al. 1993. Mol Cell Biol. 13: 7677-88. PMID: 8246984
12. P110delta, a novel phosphoinositide 3-kinase in leukocytes.  |  Vanhaesebroeck, B., et al. 1997. Proc Natl Acad Sci U S A. 94: 4330-5. PMID: 9113989

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PI 3-kinase p110δ Antibody (A-8) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-PI 3-kinase p110δ Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PI 3-kinase p110δ Antibody (A-8) Specifications

Alternate Product Name: PI3K p110 delta

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 363-582

Epitope Target: PI 3-kinase p110δ

Epitope Species: human

Product Reactivity/Detection: PI 3-kinase p110δ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for PI 3-kinase p110δ Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin