PHYHD1 Antibody (G-12): sc-398628
- PHYHD1 Antibody (G-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1-56 mapping at the N-terminus of PHYHD1 of human origin
- recommended for detection of PHYHD1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PHYHD1 Antibody (G-12) for WB applications. These reagents are now offered in bundles with PHYHD1 Antibody (G-12) (see ordering information below).
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PHYHD1 Antibody (G-12) is a mouse monoclonal IgG2a antibody that detects PHYHD1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PHYHD1, or phytanoyl-CoA dioxygenase domain containing 1, is a 291 amino acid protein that belongs to the PHYH family and the PHYHD1 subfamily, encoded by a gene located on human chromosome 9q34.11. Anti-PHYHD1 antibody (G-12) recognizes PHYHD1, which functions as an alpha-ketoglutarate-dependent dioxygenase, participating in metal ion binding and exhibiting oxidoreductase activity. Notably, PHYHD1 is involved in the degradation of phytenic acid in peroxisomes, similar to its homolog PHYH, and has been implicated in critical biological processes such as DNA methylation during early postnatal liver development and mammalian differentiation. PHYHD1′s ability to catalyze the incorporation of oxygen atoms into substrates is essential for various metabolic pathways, highlighting PHYHD1′s importance in cellular function and development. With three alternatively spliced isoforms, PHYHD1′s diverse roles in metabolism and gene regulation make PHYHD1 a significant target for research in human health and disease.
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PHYHD1 Antibody (G-12) References:
- Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. | Zhang, Z., et al. 2011. Biochem Biophys Res Commun. 408: 553-8. PMID: 21530488
- Positional cloning of the sex-linked giant egg (Ge) locus in the silkworm, Bombyx mori. | Fujii, T., et al. 2015. Insect Mol Biol. 24: 213-21. PMID: 25469867
- Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. | Miyashita, A., et al. 2014. Transl Psychiatry. 4: e396. PMID: 26126179
- Genes involved in prostate cancer progression determine MRI visibility. | Li, P., et al. 2018. Theranostics. 8: 1752-1765. PMID: 29556354
- Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles. | Cheng, S., et al. 2019. J Transl Med. 17: 407. PMID: 31796052
- A reference map of potential determinants for the human serum metabolome. | Bar, N., et al. 2020. Nature. 588: 135-140. PMID: 33177712
- Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study. | Rhee, EP., et al. 2022. Kidney Int. 101: 814-823. PMID: 35120996
- Human phytanoyl-CoA dioxygenase domain-containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism. | Ala-Nisula, T., et al. 2023. FEBS Lett. 597: 1651-1666. PMID: 37235702
- Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | Ding, X., et al. 2023. Int J Mol Sci. 24: PMID: 37686366
- Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing. | Yu, W., et al. 2024. Cell Mol Neurobiol. 44: 20. PMID: 38345650
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHYHD1 Antibody (G-12) | sc-398628 | 200 µg/ml | $322.00 | |||
PHYHD1 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-540943 | 200 µg Ab; 10 µg BP | $361.00 | |||
PHYHD1 Antibody (G-12): m-IgG2a BP-HRP Bundle | sc-546985 | 200 µg Ab; 10 µg BP | $361.00 |