Molecular structure of Phthaladyn-23, CAS Number: 404592-95-6
Phthaladyn-23 (CAS 404592-95-6)
Alternate Names:
Dynamin Inhibitor III, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
Application:
Phthaladyn-23 is an inhibitor of Dynamin I and Dynamin II
CAS Number:
404592-95-6
Molecular Weight:
465.80
Molecular Formula:
C22H12ClN3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phthaladyn-23 is a cell-permeable phthalimide compound that is reported to inhibit Dynamin I and Dynamin II GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain Dynamin I and recombinant Dynamin II, respectively) in a GTP-competitive manner. Phthaladyn-23 is shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor Dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
Inhibitor of:
Dynamin I, and Dynamin II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phthaladyn-23, 10 mg | sc-364677 | 10 mg | $153.00 |