phospholemman Antibody (A-8): sc-390822

Phospholemman Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects phospholemman in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Phospholemman, a member of the FXYD family of small membrane proteins, plays a crucial role in forming ion channels within the lipid bilayer, exhibiting unique properties such as selectivity for the zwitterion taurine and the ability to switch between anion and cation-selective conformations. This selectivity is significant as taurine acts as an osmolyte, helping to regulate cellular volume, particularly during conditions of osmotic stress. Additionally, phospholemman undergoes phosphorylation in response to adrenergic or insulin stimulation in cardiac and skeletal muscle, suggesting involvement in muscle contractility and overall cellular signaling pathways. The interaction of FXYD proteins with Na, K-ATPase in either the Golgi apparatus or plasma membrane, which varies by tissue and isotype, further highlights the potential regulatory mechanisms of phospholemman in muscle contraction. Anti-phospholemman antibody (A-8) serves as an essential tool for researchers studying cardiac and skeletal muscle function.

The preferred phospholemman antibody is phospholemman Antibody (C-1): sc-393415.