PHF1 Antibody (864C6a): sc-130646
- PHF1 Antibody (864C6a) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of PHF1 of human origin
- recommended for detection of PHF1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PHF1 Antibody (864C6a). This work is in progress.
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PHF1 Antibody (864C6a) is a mouse monoclonal IgG1 antibody that detects PHF1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. PHF1, also known as polycomb-like protein 1 or hPCI1, is a 567 amino acid member of the PHD finger protein family, which plays a crucial role in transcriptional regulation by modulating chromatin structure. PHF1 is predominantly localized in the nucleus and is widely expressed across various tissues, exhibiting particularly high levels in the pancreas, heart, and skeletal muscle, while showing lower expression in the liver, lung, kidney, brain, and placenta. The presence of two PHD-type zinc finger domains within PHF1 is significant as these domains are believed to enhance transcriptional activity, thereby influencing gene expression. PHF1 is known to interact with ENX-1, a key component of the polycomb repressive complex 2 (PRC2), which amplifies the gene silencing capabilities of PRC2, making PHF1 a vital player in the regulation of developmental processes and cellular differentiation. Additionally, PHF1 exists in two isoforms due to alternative splicing, which may further diversify functional roles in gene regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHF1 Antibody (864C6a) | sc-130646 | 100 µg/ml | $339.00 |