PGRP-S Antibody (G-1): sc-365304
- PGRP-S Antibody (G-1) is a mouse monoclonal IgG1 κ PGRP-S antibody provided at 200 µg/ml
- raised against amino acids 123-182 mapping at the C-terminus of PGRP-S of mouse origin
- PGRP-S Antibody (G-1) is recommended for detection of PGRP-S of mouse origin by WB, IP, IF and ELISA
- Anti-PGRP-S Antibody (G-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PGRP-S Antibody (G-1) for WB applications. These reagents are now offered in bundles with PGRP-S Antibody (G-1) (see ordering information below).
PGRP-S Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PGRP-S protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PGRP-S antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Peptidoglycan recognition proteins (PGRPs) play a crucial role in the immune response by recognizing peptidoglycan, a key component of bacterial cell walls. PGRP-S (G-1) monoclonal antibody is involved in the intracellular killing of Gram-positive bacteria, stimulating two essential antimicrobial defense systems: the prophenoloxidase cascade and the production of antimicrobial peptides through Toll receptors. This function helps activate the innate immune response, providing a first line of defense against bacterial infections. PGRP-S interacts with other members of the PGRP family, such as PGRP-Iα and PGRP-Iβ, which also bind to peptidoglycan but lack amidase activity, highlighting the diverse mechanisms through which the immune system can recognize and respond to pathogens. PGRP-S enhances antimicrobial pathways, underscoring its importance in maintaining host defense and preventing bacterial proliferation, making PGRP-S a significant target for research in immunology and infectious diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PGRP-S Antibody (G-1) References:
- Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. | Liu, C., et al. 2001. J Biol Chem. 276: 34686-94. PMID: 11461926
- Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. | Dziarski, R., et al. 2003. Blood. 102: 689-97. PMID: 12649138
- [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]. | Kibardin, AV., et al. 2003. Genetika. 39: 244-9. PMID: 12669421
- Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. | Wang, ZM., et al. 2003. J Biol Chem. 278: 49044-52. PMID: 14506276
- Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization. | Lo, D., et al. 2003. Cell Immunol. 224: 8-16. PMID: 14572796
- Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. | Guan, R., et al. 2005. J Mol Biol. 347: 683-91. PMID: 15769462
- Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. | Cho, JH., et al. 2005. Blood. 106: 2551-8. PMID: 15956276
- Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S. | Kumar, S., et al. 2005. J Biol Chem. 280: 37005-12. PMID: 16129677
- Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. | Tydell, CC., et al. 2006. J Immunol. 176: 1154-62. PMID: 16394004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGRP-S Antibody (G-1) | sc-365304 | 200 µg/ml | $322.00 | |||
PGRP-S Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-527351 | 200 µg Ab; 10 µg BP | $361.00 | |||
PGRP-S Antibody (G-1): m-IgG1 BP-HRP Bundle | sc-532724 | 200 µg Ab; 20 µg BP | $361.00 | |||
PGRP-S Antibody (G-1) AC | sc-365304 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PGRP-S Antibody (G-1) HRP | sc-365304 HRP | 200 µg/ml | $322.00 | |||
PGRP-S Antibody (G-1) FITC | sc-365304 FITC | 200 µg/ml | $336.00 | |||
PGRP-S Antibody (G-1) PE | sc-365304 PE | 200 µg/ml | $349.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 488 | sc-365304 AF488 | 200 µg/ml | $364.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 546 | sc-365304 AF546 | 200 µg/ml | $364.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 594 | sc-365304 AF594 | 200 µg/ml | $364.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 647 | sc-365304 AF647 | 200 µg/ml | $364.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 680 | sc-365304 AF680 | 200 µg/ml | $364.00 | |||
PGRP-S Antibody (G-1) Alexa Fluor® 790 | sc-365304 AF790 | 200 µg/ml | $364.00 |