PGRMC2 Antibody (134.6): sc-100904
- PGRMC2 Antibody (134.6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant PGRMC2 of human origin
- recommended for detection of PGRMC2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PGRMC2 Antibody (134.6). This work is in progress.
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PGRMC2 Antibody (134.6) is a mouse monoclonal IgG1 antibody that detects PGRMC2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PGRMC2, also known as DG6 or PMBP, is a single-pass membrane protein that belongs to the cytochrome b5 family, specifically the membrane-associated progesterone receptor subfamily. PGRMC2 is primarily expressed in sperm and is believed to play a crucial role as a steroid receptor, particularly in mediating the progesterone-dependent acrosome reaction, which is essential for fertilization. The acrosome reaction is a critical process that allows sperm to penetrate the outer layers of the egg, highlighting PGRMC2′s importance in reproductive biology. Additionally, PGRMC2 shares approximately 50% sequence identity with PGRMC1, indicating potential functional similarities. Notably, the loss of the gene encoding PGRMC2 has been associated with increased metastasis in uterine endocervical adenocarcinomas, suggesting PGRMC2 may have a significant role in suppressing metastasis in these cancers. Anti-PGRMC2 antibody (134.6) is an invaluable tool for researchers investigating the functions and implications of PGRMC2 in both reproductive health and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGRMC2 Antibody (134.6) | sc-100904 | 100 µg/ml | $333.00 |