PGRMC1 Antibody (12B7): sc-135720
- PGRMC1 Antibody (12B7) is a mouse monoclonal IgM κ, cited in 2 publications, provided at 200 µg/ml
- raised against retinoic acid treated NT2/D1 teratocarcinoma cells of human origin using the cyclophosphamide immunosuppression method
- recommended for detection of PGRMC1 of mouse, rat and human origin by WB, IP and IF; may cross-react with PGRMC1 of mouse origin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PGRMC1 Antibody (12B7). This work is in progress.
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PGRMC1 Antibody (12B7) is a mouse monoclonal IgM antibody that detects PGRMC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PGRMC1, also known as progesterone receptor membrane component 1 or MPR, is a 195 amino acid single-pass membrane protein that plays a critical role in mediating progesterone effects, a key steroid hormone involved in reproductive processes and embryonic development. PGRMC1 is predominantly localized in the endoplasmic reticulum and microsomes, essential for cellular signaling and hormone response. PGRMC1 presence in various tissues, particularly in the kidney and liver, underscores its importance in metabolic regulation and reproductive health. PGRMC1 contains a cytochrome b5 heme-binding domain, significant for protein interactions and potential post-translational modifications that can influence activity and stability. The gene encoding PGRMC1 is located on human chromosome X, a chromosome that not only plays a vital role in sex determination but is also associated with various genetic conditions when abnormalities occur. Anti-PGRMC1 antibody (12B7) enables researchers to gain valuable insights into the physiological and pathological roles of this important protein in different biological contexts.
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PGRMC1 Antibody (12B7) References:
- PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. | Rohe, HJ., et al. 2009. Pharmacol Ther. 121: 14-9. PMID: 18992768
- Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands. | Cahill, MA. and Medlock, AE. 2017. J Steroid Biochem Mol Biol. 171: 11-33. PMID: 28104494
- Loss of PGRMC1 Delays the Progression of Hepatocellular Carcinoma via Suppression of Pro-Inflammatory Immune Responses. | Lee, SR., et al. 2021. Cancers (Basel). 13: PMID: 34069911
- PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells. | You, JH., et al. 2021. J Exp Clin Cancer Res. 40: 350. PMID: 34749765
- Insights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division. | Lodde, V., et al. 2022. Cancers (Basel). 14: PMID: 36497237
- PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation. | Lee, SR., et al. 2023. Cells. 12: PMID: 36899888
- Clinical Importance of PGRMC1 in Hormone Responsive Breast Cancer. | Ruan, X. and Mueck, AO. 2023. Breast Care (Basel). 18: 172-178. PMID: 37529370
- Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells. | Tsuru, A., et al. 2023. J Pharmacol Sci. 153: 188-196. PMID: 37973216
- Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism. | Wang, F., et al. 2024. J Reprod Immunol. 163: 104244. PMID: 38555747
- PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR. | Guan, A., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167440. PMID: 39059592
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGRMC1 Antibody (12B7) | sc-135720 | 200 µg/ml | $322.00 |