PGI2 synthase Antibody (3B11): sc-293247

PGI2 synthase Antibody (3B11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PGI2 synthase protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PGI2 synthase antibody (3B11) is available as the non-conjugated format. PGI2 synthase enzyme plays a crucial role in cardiovascular health by catalyzing the conversion of prostaglandin H2 to prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This function is vital as prostacyclin helps regulate blood flow and prevent thrombosis, thereby maintaining vascular homeostasis. PGI2 synthase is unique within the cytochrome P450 superfamily, as PGI2 synthase does not exhibit monooxygenase activity and does not require an external electron source for enzymatic reaction. PGI2 synthase consists of 500 amino acids and shares sequence homology with cholesterol 7-alpha-monooxygenase, indicating evolutionary significance. The gene encoding PGI2 synthase is located on human chromosome 20q13.13, highlighting importance in human genetics and potential implications in various cardiovascular diseases.

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PGI2 synthase Antibody (3B11) References:

1. Cloning and characterization of 5'-flanking region of mouse prostacyclin synthase gene.  |  Ohkawara, S., et al. 2000. Biochim Biophys Acta. 1494: 155-61. PMID: 11072079
2. Regulation of prostacyclin synthesis by angiotensin II and TNF-alpha in vascular smooth muscle.  |  Askari, B. and Ferreri, NR. 2001. Prostaglandins Other Lipid Mediat. 63: 175-87. PMID: 11305695
3. Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis.  |  Spisni, E., et al. 2001. Exp Cell Res. 266: 31-43. PMID: 11339822
4. Substrate access channel topology in membrane-bound prostacyclin synthase.  |  Deng, H., et al. 2002. Biochem J. 362: 545-51. PMID: 11879180
5. Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation.  |  Bachschmid, M., et al. 2003. FASEB J. 17: 914-6. PMID: 12670882
6. Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase.  |  Deng, H., et al. 2003. Biochemistry. 42: 5609-17. PMID: 12741817
7. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness.  |  Hashimoto, K., et al. 2004. J Virol. 78: 10303-9. PMID: 15367596
8. Molecular cloning and expression of human prostacyclin synthase.  |  Miyata, A., et al. 1994. Biochem Biophys Res Commun. 200: 1728-34. PMID: 8185632
9. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity.  |  Yokoyama, C., et al. 1996. Genomics. 36: 296-304. PMID: 8812456
10. Organization of the gene encoding human prostacyclin synthase.  |  Wang, LH. and Chen, L. 1996. Biochem Biophys Res Commun. 226: 631-7. PMID: 8831668
11. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.  |  Nelson, DR., et al. 1996. Pharmacogenetics. 6: 1-42. PMID: 8845856
12. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats.  |  Todaka, T., et al. 1999. Stroke. 30: 419-26. PMID: 9933282

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGI2 synthase Antibody (3B11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PGI2 synthase Antibody (3B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGI2 synthase Antibody (3B11) Specifications

Alternate Product Name: PGI2 synthase

Product Clone Name: 3B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 391-500

Epitope Target: PGI2 synthase

Epitope Species: human

Product Reactivity/Detection: PGI2 synthase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PGI2 synthase Antibody (3B11): N/A