PGD2 synthase Antibody (G-5): sc-393865

PGD2 synthase Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects PGD2 synthase in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PGD2 synthase plays a crucial role in the synthesis of prostaglandin D2, a lipid mediator involved in various physiological processes, including the regulation of sleep, inflammation, and allergic responses. PGD2 synthase is primarily located in the cytoplasm of specific cell types, such as human megakaryoblastic CMK cells, where PGD2 synthase is essential for PGD2 production, particularly in the brain. Understanding the cellular localization of PGD2 synthase is vital, as PGD2 synthase highlights functional significance in mediating responses to inflammatory stimuli and potential implications in various diseases, including asthma and neurodegenerative disorders. PGD2 synthase is distinct from PGD synthase, as PGD2 synthase does not require glutathione for activity, showcasing the diversity of regulatory mechanisms within the prostaglandin synthesis pathway. The human PGD2 synthase gene is located on chromosome 9q34.3, and PGD2 synthase expression patterns can vary significantly between species, emphasizing the importance of using species-specific anti-PGD2 synthase antibody (G-5) for accurate research outcomes.

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PGD2 synthase Antibody (G-5) References:

1. Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia.  |  Maesaka, JK., et al. 2002. Semin Nephrol. 22: 407-14. PMID: 12224048
2. Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues.  |  Jowsey, IR., et al. 2003. Prostaglandins Other Lipid Mediat. 70: 267-84. PMID: 12611492
3. Expression of prostaglandin D2 synthase in activated eosinophils in nasal polyps.  |  Hyo, S., et al. 2007. Arch Otolaryngol Head Neck Surg. 133: 693-700. PMID: 17638783
4. Prostaglandin D2 synthase: Apoptotic factor in alzheimer plasma, inducer of reactive oxygen species, inflammatory cytokines and dialysis dementia.  |  Maesaka, JK., et al. 2013. J Nephropathol. 2: 166-80. PMID: 24475446
5. Role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth.  |  Kumar, S., et al. 2015. Prostaglandins Other Lipid Mediat. 118-119: 28-33. PMID: 25964109
6. Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase.  |  Urbanet, R., et al. 2015. Hypertension. 66: 149-57. PMID: 25966493
7. Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.  |  Meleza, C., et al. 2016. Anal Biochem. 511: 17-23. PMID: 27485270
8. Lipocalin-type Prostaglandin D2 Synthase appears to function as a Novel Adipokine Preventing Adipose Dysfunction in response to a High Fat Diet.  |  Srivastava, A., et al. 2021. Prostaglandins Other Lipid Mediat. 157: 106585. PMID: 34371198
9. Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation.  |  Cui, J., et al. 2023. Molecules. 28: PMID: 37570903
10. Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain.  |  García-Fernández, LF., et al. 1997. Eur J Neurosci. 9: 1566-73. PMID: 9283811

The preferred PGD2 synthase antibody is PGD2 synthase Antibody (F-7): sc-390717.