Molecular structure of PF-543, CAS Number: 1415562-82-1
PF-543 (CAS 1415562-82-1)
Alternate Names:
Sphingosine Kinase 1 Inhibitor II
CAS Number:
1415562-82-1
Molecular Weight:
465.60
Molecular Formula:
C27H31NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PF-543 (CAS 1415562-82-1) References
- Crystal Structure of Sphingosine Kinase 1 with PF-543. | Wang, J., et al. 2014. ACS Med Chem Lett. 5: 1329-33. PMID: 25516793
- Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543. | Ju, T., et al. 2016. Biochem Biophys Res Commun. 470: 728-734. PMID: 26775841
- Synthesis and Biological Evaluation of PF-543 Derivative Containing Aliphatic Side Chain. | Kim, SW., et al. 2019. Chem Pharm Bull (Tokyo). 67: 599-603. PMID: 31155566
- Synthesis and Biological Evaluation of BODIPY-PF-543. | Shrestha, J., et al. 2019. Molecules. 24: PMID: 31810327
- Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity. | Kim, SB., et al. 2020. Molecules. 25: PMID: 32471162
- A Dansyl-Modified Sphingosine Kinase Inhibitor DPF-543 Enhanced De Novo Ceramide Generation. | Shamshiddinova, M., et al. 2021. Int J Mol Sci. 22: PMID: 34502095
- Synthesis of PP2A-Activating PF-543 Derivatives and Investigation of Their Inhibitory Effects on Pancreatic Cancer Cells. | Kim, SB., et al. 2022. Molecules. 27: PMID: 35630821
- Novel Dimer Derivatives of PF-543 as Potential Antitumor Agents for the Treatment of Non-Small Cell Lung Cancer. | Kim, SB., et al. 2022. Pharmaceutics. 14: PMID: 36297469
- Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543. | Yi, X., et al. 2023. Biomed Pharmacother. 163: 114401. PMID: 37167721
- Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells. | Wang, D., et al. 2023. Gastroenterology. 165: 1488-1504.e20. PMID: 37634735
Inhibitor of:
ACSVL5, C1orf53, EDG-1, HAS1, MFSD2B, SNX8, SphK1, SphK2, SPHKAP, SYDE2, TREML6, and Ypk1.Activator of:
ACP6, EDG-5, and SGK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PF-543, 10 mg | sc-507507 | 10 mg | $210.00 |