period Antibody (H-3): sc-398462
- period Antibody (H-3) is a mouse monoclonal IgG2a κ period antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 925-1224 mapping at the C-terminus of period of Drosophila melanogaster origin
- period Antibody (H-3) is recommended for detection of all period isoforms of d origin by WB, IP, IF and ELISA
- Anti-period Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for period Antibody (H-3) for WB applications. These reagents are now offered in bundles with period Antibody (H-3) (see ordering information below).
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SEE ALSO...
Period Antibody (H-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects period protein of Drosophila melanogaster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-period antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Period protein functions as a DNA-binding transcription factor regulating circadian rhythms, which are essential for maintaining physiological processes that follow a roughly 24-hour cycle, such as sleep-wake patterns, hormone release, and metabolism. Disruptions in circadian rhythms can lead to various health issues, including sleep disorders, metabolic syndrome, and certain cancers, highlighting the significance of studying period protein in both basic biology and potential therapeutic interventions. Drosophila melanogaster serves as an invaluable model organism for investigating these processes, as many genetic and physiological similarities are shared with higher eukaryotes, making period protein research highly relevant to understanding circadian biology in humans.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
period Antibody (H-3) References:
- The genome sequence of Drosophila melanogaster. | Adams, MD., et al. 2000. Science. 287: 2185-95. PMID: 10731132
- Product of per locus of Drosophila shares homology with proteoglycans. | Jackson, FR., et al. Nature. 320: 185-8. PMID: 3081818
- The period clock locus of D. melanogaster codes for a proteoglycan. | Reddy, P., et al. 1986. Cell. 46: 53-61. PMID: 3087625
- A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. | Citri, Y., et al. Nature. 326: 42-7. PMID: 3102970
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
period Antibody (H-3) | sc-398462 | 200 µg/ml | $316.00 | |||
period Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-530807 | 200 µg Ab; 10 µg BP | $354.00 | |||
period Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-524351 | 200 µg Ab, 40 µg BP | $354.00 | |||
period Antibody (H-3) AC | sc-398462 AC | 500 µg/ml, 25% agarose | $416.00 | |||
period Antibody (H-3) HRP | sc-398462 HRP | 200 µg/ml | $316.00 | |||
period Antibody (H-3) FITC | sc-398462 FITC | 200 µg/ml | $330.00 | |||
period Antibody (H-3) PE | sc-398462 PE | 200 µg/ml | $343.00 | |||
period Antibody (H-3) Alexa Fluor® 488 | sc-398462 AF488 | 200 µg/ml | $357.00 | |||
period Antibody (H-3) Alexa Fluor® 546 | sc-398462 AF546 | 200 µg/ml | $357.00 | |||
period Antibody (H-3) Alexa Fluor® 594 | sc-398462 AF594 | 200 µg/ml | $357.00 | |||
period Antibody (H-3) Alexa Fluor® 647 | sc-398462 AF647 | 200 µg/ml | $357.00 | |||
period Antibody (H-3) Alexa Fluor® 680 | sc-398462 AF680 | 200 µg/ml | $357.00 | |||
period Antibody (H-3) Alexa Fluor® 790 | sc-398462 AF790 | 200 µg/ml | $357.00 |