Per3 Antibody (4B9D7): sc-517227
- Per3 Antibody (4B9D7) is a mouse monoclonal IgG2b Per3 antibody, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against a recombinant protein corresponding to amino acids 723-954 of Per3 of human origin
- recommended for detection of Per3 of human origin by WB, IP, IF, IHC(P), FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Per3 Antibody (4B9D7). This work is in progress.
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Per3 Antibody (4B9D7) is a mouse monoclonal IgG2b antibody that detects the Per3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Per3 (4B9D7) antibody is available as the non-conjugated anti-Per3 antibody. Per3 protein plays a crucial role in the regulation of circadian rhythms, which are essential for maintaining various physiological processes, including sleep-wake cycles and hormonal secretions. Located primarily in the suprachiasmatic nucleus (SCN) of the brain, Per3 is one of the three mammalian period proteins, alongside Per1 and Per2, that contribute to the molecular mechanisms of the circadian clock. Per3 exhibits unique expression patterns, as Per3 RNA levels remain stable in response to light pulses during subjective night, unlike Per1 and Per2, which increase. This differential regulation highlights Per3′s importance in maintaining the stability of circadian rhythms. Per3 interacts with other key proteins involved in the circadian clock, such as Timeless (Tim), which is known to negatively regulate Clock-BMAL1-induced transcription alongside Per1. Understanding Per3 function and interactions is vital for elucidating the complexities of circadian biology and its implications for health and disease.
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Per3 Antibody (4B9D7) References:
- Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system. | Nadkarni, NA., et al. 2005. J Biol Rhythms. 20: 490-9. PMID: 16275768
- Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms. | Numano, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 3716-21. PMID: 16537451
- Circadian oscillation of gene expression in murine calvarial bone. | Zvonic, S., et al. 2007. J Bone Miner Res. 22: 357-65. PMID: 17144790
- PER3 polymorphism predicts sleep structure and waking performance. | Viola, AU., et al. 2007. Curr Biol. 17: 613-8. PMID: 17346965
- A 24-hour circadian clock is found in the mammalian retina. | Morell, V. 1996. Science. 272: 349. PMID: 8602520
- Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. | Antoch, MP., et al. 1997. Cell. 89: 655-67. PMID: 9160756
- The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. | King, DP., et al. 1997. Genetics. 146: 1049-60. PMID: 9215907
- Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. | Zylka, MJ., et al. 1998. Neuron. 20: 1103-10. PMID: 9655499
- Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. | Sangoram, AM., et al. 1998. Neuron. 21: 1101-13. PMID: 9856465
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Per3 Antibody (4B9D7) | sc-517227 | 50 µg/0.5 ml | $322.00 |