Per3 Activators
Per3 Activators belong to a distinctive chemical class characterized by their ability to modulate the expression and activity of the Period 3 (Per3) gene, which encodes a critical component of the circadian clock in mammals. The circadian clock is an intrinsic, time-keeping system that regulates various physiological and behavioral processes, including sleep-wake cycles, hormonal secretion, and metabolic activities, in a roughly 24-hour rhythm. Per3 is one of the core clock genes responsible for maintaining the circadian rhythm, and its activation or inhibition can influence the overall functioning of the circadian clock.
Chemically, Per3 Activators are compounds that interact with specific regulatory elements of the Per3 gene, resulting in enhanced transcription and translation of the Per3 protein. This increased expression of Per3 can subsequently impact the phase and amplitude of the circadian oscillations. The precise mechanisms through which Per3 Activators exert their effects on Per3 gene expression may vary, but they often involve interactions with transcription factors or chromatin-modifying enzymes. By modulating Per3 activity, these compounds can fine-tune the circadian clock, leading to altered sleep patterns, hormone secretion, and metabolic processes. Furthermore, Per3 Activators can be invaluable tools in scientific research, allowing investigators to dissect the intricate workings of the circadian clock. These compounds enable researchers to gain insights into the fundamental biology of circadian rhythms and may have applications in fields ranging from chronobiology to neuroscience and beyond.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates Per3 by stimulating the cAMP (cyclic adenosine monophosphate) pathway. It increases cAMP levels, which can lead to the activation of Per3 and other circadian genes through the cAMP response element-binding protein (CREB). | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that influences the expression of circadian genes, including Per3. It is thought to affect Per3 by modulating the activity of transcription factors involved in the circadian clock. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, can impact Per3 expression by interacting with retinoic acid receptors (RARs) and retinoid X receptors (RXRs). These receptors can modulate the transcription of Per3. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid has been found to affect circadian rhythms, potentially including the regulation of Per3. Its exact mechanism of action on Per3 is not fully understood but may involve histone modification. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to influence circadian rhythms and may impact Per3 expression. It could do so through various pathways, including the glycogen synthase kinase-3 (GSK-3) pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA demethylating agent. It may activate Per3 by demethylating the gene's promoter region, allowing for increased gene expression. | ||||||
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Nobiletin, found in citrus fruits, has been investigated for its effects on circadian rhythms. It may activate Per3 through various signaling pathways, but the exact mechanism is not well-defined. | ||||||
6-Formylindolo[3,2-b]carbazole | 172922-91-7 | sc-300019A sc-300019 | 100 µg 5 mg | $105.00 $2185.00 | 5 | |
FICZ activates the aryl hydrocarbon receptor (AhR), which is linked to the regulation of circadian genes like Per3. Activation of AhR by FICZ can lead to Per3 expression. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in various cellular processes, including circadian rhythm regulation. It may activate Per3 indirectly by influencing the activity of enzymes and co-factors involved in circadian gene expression. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin is a hormone that regulates the sleep-wake cycle and can influence circadian gene expression, including Per3. It does so by binding to melatonin receptors and signaling downstream pathways. | ||||||