Per2 Antibody (C-6): sc-377290

Per2 Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Per2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Per2 antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Per2 protein plays a crucial role in regulating circadian rhythms, which are essential for maintaining the body′s internal clock and synchronizing physiological processes with the day-night cycle. Located primarily in the suprachiasmatic nucleus (SCN) of the brain, Per2 is involved in the transcriptional feedback loop that regulates the expression of other clock genes, thereby influencing sleep-wake cycles, hormonal rhythms, and metabolic processes. Per2 interacts with other core clock proteins, such as Clock and BMAL1, to modulate their activity, and disruptions in Per2 function can lead to sleep disorders and metabolic syndromes. Understanding Per2 dynamics and interactions is vital for elucidating the mechanisms underlying circadian biology and its implications for health and disease.

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Per2 Antibody (C-6) References:

1. 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity.  |  Kubo, Y., et al. 2012. J Pharmacol Exp Ther. 340: 698-705. PMID: 22171092
2. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.  |  Kobayashi, M., et al. 2017. FEBS J. 284: 3804-3816. PMID: 28963769
3. PER2 regulation of mammary gland development.  |  McQueen, CM., et al. 2018. Development. 145: PMID: 29490985
4. Interaction between corticosterone and PER2 in regulating emotional behaviors in the rat.  |  Ionadi, A. and Johnson, JD. 2022. Psychoneuroendocrinology. 137: 105628. PMID: 34952453
5. Diversity of genetic platforms harboring the blaPER-2 gene in Enterobacterales and insights into the role of ISPa12 in its mobilization and dissemination.  |  Ruggiero, M., et al. 2023. Int J Antimicrob Agents. 62: 106850. PMID: 37178777
6. Multitissue Circadian Proteome Atlas of WT and Per1-/-/Per2-/- Mice.  |  Qian, L., et al. 2023. Mol Cell Proteomics. 22: 100675. PMID: 37940002
7. Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis.  |  Ye, Y., et al. 2024. Mucosal Immunol. 17: 1161-1173. PMID: 39097147
8. A 24-hour circadian clock is found in the mammalian retina.  |  Morell, V. 1996. Science. 272: 349. PMID: 8602520
9. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.  |  Antoch, MP., et al. 1997. Cell. 89: 655-67. PMID: 9160756
10. The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.  |  King, DP., et al. 1997. Genetics. 146: 1049-60. PMID: 9215907
11. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.  |  Zylka, MJ., et al. 1998. Neuron. 20: 1103-10. PMID: 9655499
12. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.  |  Sangoram, AM., et al. 1998. Neuron. 21: 1101-13. PMID: 9856465

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Per2 Antibody (C-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Per2 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Per2 Antibody (C-6) Specifications

Alternate Product Name: Period circadian regulator 2

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-90

Epitope Target: Per2

Epitope Species: human

Product Reactivity/Detection: Per2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Per2 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent