PEPD Antibody (47-Q): sc-100708

PEPD Antibody (47-Q) is a mouse monoclonal IgG1 antibody that detects PEPD (peptidase D) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PEPD is a cytosolic dipeptidase belonging to the peptidase M24B family and plays a crucial role in collagen metabolism and proline recycling, which is vital for maintaining structural integrity of various tissues. PEPD functions as a homodimer, enabling effective hydrolysis of di- and tripeptides containing proline or hydroxyproline at the C-terminus. Deficiencies in PEPD can lead to prolidase deficiency, an autosomal recessive disorder characterized by symptoms such as skin ulcers, mental retardation, recurrent infections, and atypical facial features. Mutations in PEPD have been implicated in systemic lupus erythematosus and necrosis-like cell death in fibroblasts, highlighting PEPD′s significance in both metabolic processes and disease pathology. Anti-PEPD antibody (47-Q) serves as an essential tool for researchers studying PEPD′s implications in health and disease, providing insights into functional roles and potential therapeutic targets.

The preferred PEPD antibody is PEPD Antibody (A-3): sc-390042.