CD31/PECAM-1 Antibody (RM0032-1D12): sc-101454

PECAM-1 Antibody (RM0032-1D12) is a rat monoclonal IgG2a antibody that detects PECAM-1 in mouse samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). PECAM-1, also known as CD31, is a crucial glycoprotein that plays a significant role in regulating leukocyte migration and angiogenesis, making PECAM-1 essential for maintaining vascular integrity and facilitating immune responses. PECAM-1 is predominantly located at intercellular junctions of endothelial cells, where PECAM-1 mediates cell-cell adhesion and communication, thereby influencing blood vessel permeability and immune cell transmigration during inflammatory responses. Proper functioning of PECAM-1 is vital for normal physiological processes, as PECAM-1 dysregulation can lead to various pathological conditions, including chronic inflammation and tumor metastasis. Through interactions with other adhesion molecules and signaling proteins, PECAM-1 serves as a key player in the complex network of cellular interactions governing tissue homeostasis and immune surveillance. Anti-PECAM-1 antibody (RM0032-1D12) provides reliable detection and characterization of PECAM-1 in mouse tissues for researchers studying vascular biology, immunology, and related fields.

The preferred CD31/PECAM-1 antibody is CD31/PECAM-1 Antibody (MEC 13.3): sc-18916.