CD31/PECAM-1 Antibody (MEC 13.3): sc-18916

PECAM-1 Antibody (MEC 13.3) is a rat monoclonal IgG2a antibody that detects PECAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). PECAM-1, also known as CD31, is a crucial glycoprotein that plays a significant role in mediating cell-cell adhesion, particularly in the vascular system, where PECAM-1 is predominantly expressed on the surfaces of endothelial cells, platelets, and certain leukocytes. PECAM-1 is essential for maintaining vascular integrity and facilitating leukocyte transmigration during inflammatory responses, making PECAM-1 a key player in both immune function and tissue homeostasis. PECAM-1 is also involved in angiogenesis, the process of new blood vessel formation, which is vital for wound healing and tissue repair. Anti-PECAM-1 antibody (MEC 13.3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. By utilizing PECAM-1 monoclonal antibody (MEC 13.3), researchers can gain insights into the dynamics of cell adhesion and migration, which are critical for understanding various physiological and pathological processes, including cancer metastasis and cardiovascular diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD31/PECAM-1 Antibody (MEC 13.3) References:

1. PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells.  |  Saragih, H., et al. 2014. Thromb Haemost. 111: 1077-88. PMID: 24500083
2. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin.  |  Bruggisser, J., et al. 2020. Cell Host Microbe. 28: 69-78.e6. PMID: 32497498
3. Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.  |  Jørgensen, OS. 1995. Neurochem Res. 20: 533-47. PMID: 7643959
4. Cell adhesion receptors and early mammalian heart development: an overview.  |  Buck, CA., et al. 1993. C R Acad Sci III. 316: 838-59. PMID: 8076214
5. Congenital heart disease: three years of surgery.  |  McCue, CM., et al. 1977. Va Med. 104: 22-9. PMID: 831372
6. Vase mini-exon usage by NCAM is not restricted to tumours of neuroectodermal origin.  |  Patel, K., et al. 1993. Int J Cancer. 54: 772-7. PMID: 8325706
7. The Kallmann's syndrome variant (KSV) model of the schizophrenias.  |  Cowen, MA. and Green, M. 1993. Schizophr Res. 9: 1-10. PMID: 8461265
8. Bone marrow micrometastases in a patient with localized Wilms' tumor.  |  Dominici, C., et al. 1996. Med Pediatr Oncol. 26: 125-8. PMID: 8531850
9. Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among integrin-Ig family interactions.  |  Briskin, MJ., et al. 1996. J Immunol. 156: 719-26. PMID: 8543825
10. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.  |  Berman, ME., et al. 1996. J Immunol. 156: 1515-24. PMID: 8568255
11. Developmental control of N-CAM expression by Hox and Pax gene products.  |  Edelman, GM. and Jones, FS. 1995. Philos Trans R Soc Lond B Biol Sci. 349: 305-12. PMID: 8577842

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD31/PECAM-1 Antibody (MEC 13.3) has 119 citations in a variety of scientific publications.

Primary antibodies like Anti-CD31/PECAM-1 Antibody (MEC 13.3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD31/PECAM-1 Antibody (MEC 13.3) Specifications

Alternate Product Name: CD31

Product Clone Name: MEC 13.3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: PECAM-1

Epitope Species: mouse

Product Reactivity/Detection: PECAM-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 119 citations in various scientific publications

Available Conjugates/Forms for CD31/PECAM-1 Antibody (MEC 13.3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin