CD31/PECAM-1 Antibody (ER-MP12): sc-52713

PECAM-1 Antibody (ER-MP12) is a rat monoclonal IgG2a antibody that detects PECAM-1 in mouse samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). PECAM-1, also known as CD31, is a crucial glycoprotein expressed on the surfaces of various immune cells, including monocytes, neutrophils, platelets, and a subset of T cells, playing a vital role in mediating cell-cell adhesion and transendothelial migration. PECAM-1 is predominantly located at the intercellular junctions of endothelial cells, where PECAM-1 facilitates the passage of leukocytes from the bloodstream into tissues, a process essential for immune response and inflammation. Proper functioning of PECAM-1 is critical, as dysregulation can lead to impaired immune responses and contribute to various pathological conditions, including chronic inflammation and tumor metastasis. Anti-PECAM-1 antibody (ER-MP12) is an invaluable tool for researchers studying vascular biology, immune cell interactions, and the mechanisms underlying inflammatory diseases, providing insights into the complex roles of cell adhesion molecules in health and disease.

The preferred CD31/PECAM-1 antibody is CD31/PECAM-1 Antibody (MEC 13.3): sc-18916.