PEBP2β Antibody (141,4,1): sc-56751

PEBP2β Antibody (141,4,1) is a mouse monoclonal IgG2a antibody that detects PEBP2 beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PEBP2β (141,4,1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PEBP2 beta protein, a crucial component of the Polyomavirus enhancer binding protein 2 (PEBP2), plays a significant role in regulating hematopoiesis and osteogenesis. PEBP2 beta forms a heterodimer with PEBP2 alpha subunit, essential for DNA binding and transcriptional regulation. This interaction between subunits is vital for proper development of blood cells and bone tissue; disruption of either subunit leads to severe developmental issues, including lack of definitive hematopoiesis and subsequent embryonic lethality due to central nervous system hemorrhage. PEBP2β gene is implicated in acute myeloid leukemia through a chromosomal inversion that creates a chimeric gene associated with this malignancy. This significance in normal physiological processes and cancer pathology makes anti-PEBP2β antibody (141,4,1) a valuable tool for research in both developmental biology and oncology.

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PEBP2β Antibody (141,4,1) References:

1. Regulation mechanisms for the heterodimeric transcription factor, PEBP2/CBF.  |  Bae, SC. and Ito, Y. 1999. Histol Histopathol. 14: 1213-21. PMID: 10506937
2. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.  |  Hanai, J., et al. 1999. J Biol Chem. 274: 31577-82. PMID: 10531362
3. Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31.  |  Namba, K., et al. 2000. Oncogene. 19: 106-14. PMID: 10644985
4. The PEBP2beta/CBF beta-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16.  |  Kanto, S., et al. 2000. Leukemia. 14: 1253-9. PMID: 10914550
5. Biological implications of filamin A-bound PEBP2beta/CBFbeta retention in the cytoplasm.  |  Watanabe, T., et al. 2005. Crit Rev Eukaryot Gene Expr. 15: 197-206. PMID: 16390316
6. PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.  |  Wee, HJ., et al. 2008. Blood. 112: 3777-87. PMID: 18695000
7. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer.  |  Kamachi, Y., et al. 1990. J Virol. 64: 4808-19. PMID: 2168969
8. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.  |  Nuchprayoon, I., et al. 1994. Mol Cell Biol. 14: 5558-68. PMID: 8035830
9. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.  |  Ogawa, E., et al. 1993. Proc Natl Acad Sci U S A. 90: 6859-63. PMID: 8341710
10. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha.  |  Ogawa, E., et al. 1993. Virology. 194: 314-31. PMID: 8386878
11. The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation.  |  Tanaka, Y., et al. 1998. Oncogene. 17: 699-708. PMID: 9715271
12. Acute myelomonoblastic leukemia carrying the PEBP2beta/MYH11 fusion gene.  |  Asou, N., et al. 1998. Leuk Lymphoma. 31: 81-91. PMID: 9720717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PEBP2β Antibody (141,4,1) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-PEBP2β Antibody (141,4,1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PEBP2β Antibody (141,4,1) Specifications

Alternate Product Name: CBFB

Product Clone Name: 141,4,1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-141

Epitope Target: PEBP2β

Epitope Species: mouse

Product Reactivity/Detection: PEBP2β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for PEBP2β Antibody (141,4,1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin