PEA3 Antibody (1A2G3): sc-130661
- PEA3 Antibody (1A2G3) is a mouse monoclonal IgG1 λ, cited in 2 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 50-109 of PEA3 of human origin
- recommended for detection of PEA3 of mouse, rat and human origin by WB, IP and ELISA
- See PEA3 (G-10): sc-166629 for PEA3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PEA3 Antibody (1A2G3) for WB applications. These reagents are now offered in bundles with PEA3 Antibody (1A2G3) (see ordering information below).
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PEA3 Antibody (1A2G3) is a mouse monoclonal IgG1 antibody that detects PEA3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PEA3, a member of the Ets gene family, plays a crucial role in regulating gene expression by binding to specific DNA motifs, which is essential for various cellular processes, including development and differentiation. PEA3 is particularly important in epithelial and fibroblastic cells, where expression reaches detectable levels, contrasting with other Ets family members that are primarily found in hematopoietic cells. Anti-PEA3 antibody (1A2G3) recognizes and binds to the PEA-3 motif (5′-AGGAAG-3′) while showing specificity for unique flanking sequences, highlighting its role in fine-tuning gene regulation. PEA3 (1A2G3) monoclonal antibody serves as an invaluable tool for researchers studying the intricate mechanisms of gene expression and the functional implications of PEA3 in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PEA3 Antibody (1A2G3) References:
- The PEA3 group of ETS-related transcription factors. Role in breast cancer metastasis. | de Launoit, Y., et al. 2000. Adv Exp Med Biol. 480: 107-16. PMID: 10959416
- Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. | Kurpios, NA., et al. 2003. J Mammary Gland Biol Neoplasia. 8: 177-90. PMID: 14635793
- PEA3 cooperates with c-Jun in regulation of HER2/neu transcription. | Matsui, K., et al. 2006. Oncol Rep. 16: 153-8. PMID: 16786139
- Pea3 transcription factor promotes neurite outgrowth. | Kandemir, B., et al. 2014. Front Mol Neurosci. 7: 59. PMID: 25018694
- Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma. | Mesci, A., et al. 2014. World J Gastroenterol. 20: 17376-87. PMID: 25516649
- Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation. | Kandemir, B., et al. 2020. Neurosci Lett. 738: 135348. PMID: 32891673
- Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway. | Cheng, WH., et al. 2021. Mol Med. 27: 69. PMID: 34229599
- Transcription factor gene Pea3 regulates erectile function during copulation in mice. | Weinrich, JAP., et al. 2022. PLoS One. 17: e0276069. PMID: 36301850
- Targeting PEA3 transcription factors to mitigate small cell lung cancer progression. | Shia, DW., et al. 2023. Oncogene. 42: 434-448. PMID: 36509998
- Structure-function relationships of the PEA3 group of Ets-related transcription factors. | de Launoit, Y., et al. 1997. Biochem Mol Med. 61: 127-35. PMID: 9259977
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PEA3 Antibody (1A2G3) | sc-130661 | 200 µg/ml | $322.00 | |||
PEA3 Antibody (1A2G3): m-IgG Fc BP-HRP Bundle | sc-539835 | 200 µg Ab; 10 µg BP | $361.00 | |||
PEA3 Antibody (1A2G3): m-IgG1 BP-HRP Bundle | sc-541741 | 200 µg Ab; 20 µg BP | $361.00 |