PDK3 Antibody (RR-2): sc-100535
- PDK3 Antibody (RR-2) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant PDK3 of human origin
- recommended for detection of PDK3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDK3 Antibody (RR-2). This work is in progress.
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PDK3 Antibody (RR-2) is a mouse monoclonal IgG2a light chain antibody that detects pyruvate dehydrogenase kinase 3 (PDK3) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PDK3 plays a crucial role in cellular metabolism by regulating the activity of the pyruvate dehydrogenase complex (PDC), which is essential for converting pyruvate into acetyl-CoA, a key substrate for the citric acid cycle. This regulation is particularly important during metabolic stress, such as starvation, when the body shifts its energy production pathways. PDK3 achieves this by phosphorylating the E1α subunit of PDC, leading to its inactivation, thereby preventing the conversion of pyruvate to acetyl-CoA and promoting fatty acid oxidation instead. The expression of PDK3 is notably high in the testis and is also present in heart and skeletal muscle, indicating its significant role in energy metabolism across different tissues. The protein′s structure includes five conserved regions that are similar to bacterial His-kinases, highlighting its evolutionary significance and the necessity of histidine residues for its kinase activity. Anti-PDK3 antibody (RR-2) is an invaluable tool for researchers studying metabolic regulation and the physiological implications of PDK3 in various biological contexts.
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PDK3 Antibody (RR-2) References:
- Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia. | Cui, L., et al. 2020. Cancer Gene Ther. 27: 15-21. PMID: 30578412
- Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance. | Xu, J., et al. 2019. Theranostics. 9: 2999-3013. PMID: 31244938
- miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3. | Feng, L., et al. 2019. Biosci Rep. 39: PMID: 31409724
- The lncRNA-DLEU2/miR-186-5p/PDK3 axis promotes the progress of glioma cells. | Xie, Z., et al. 2019. Am J Transl Res. 11: 4922-4934. PMID: 31497209
- The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis. | Tian, K., et al. 2024. Cancer Cell Int. 24: 91. PMID: 38429830
- Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3. | Dong, Q., et al. 2025. Mol Cell Biochem. 480: 355-369. PMID: 38466468
- PDK3 drives colorectal carcinogenesis and immune evasion and is a therapeutic target for boosting immunotherapy. | Liu, Z., et al. 2024. Am J Cancer Res. 14: 3117-3129. PMID: 39005672
- Pdk3's role in RANKL-induced osteoclast differentiation: insights from a bone marrow macrophage model. | Zhang, N., et al. 2024. PeerJ. 12: e18222. PMID: 39399421
- Melittin suppresses aerobic glycolysis by regulating HSF1/PDK3 to increase chemosensitivity of NSCLC. | Wang, Y., et al. 2025. Eur J Pharmacol. 986: 177084. PMID: 39547404
- Exploring PDK3 inhibition in lung cancer through drug repurposing for potential therapeutic interventions. | Khan, ZF., et al. 2024. Sci Rep. 14: 29672. PMID: 39613779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDK3 Antibody (RR-2) | sc-100535 | 100 µg/ml | $339.00 |