PDGF-C Antibody (KJ-13): sc-80290

PDGF-C Antibody (KJ-13) is a rat monoclonal IgG1 antibody that detects PDGF-C protein of mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-PDGF-C antibody (KJ-13) is available as a non-conjugated format. The platelet-derived growth factor (PDGF) family, which includes PDGF-C, plays a crucial role in cellular processes such as growth, survival, and tissue repair, particularly in connective tissue cells. PDGF-C, also known as spinal cord-derived growth factor or fallotein, is a functional analog of PDGF-A and requires proteolytic activation to become biologically active. This activation allows PDGF-C to selectively bind to and activate PDGF receptor alpha (PDGFR-α), which is critical for mediating cellular responses such as proliferation and migration in vascular smooth muscle cells and pericytes. PDGF-C expression in the arterial wall and cultured vascular cells indicates a significant role in vascular biology and potential involvement in pathological conditions like arteriosclerosis. PDGF-C is subject to transcriptional deregulation by EWS/ETS fusion proteins, particularly EWS/FLI, highlighting relevance in certain cancers and importance in both normal physiology and disease contexts.

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PDGF-C Antibody (KJ-13) References:

1. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.  |  Hamada, T., et al. 2001. Biochem Biophys Res Commun. 280: 733-7. PMID: 11162582
2. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.  |  Zwerner, JP. and May, WA. 2001. Oncogene. 20: 626-33. PMID: 11313995
3. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.  |  Bergsten, E., et al. 2001. Nat Cell Biol. 3: 512-6. PMID: 11331881
4. PDGF-D, a new protease-activated growth factor.  |  LaRochelle, WJ., et al. 2001. Nat Cell Biol. 3: 517-21. PMID: 11331882
5. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.  |  Uutela, M., et al. 2001. Circulation. 103: 2242-7. PMID: 11342471

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDGF-C Antibody (KJ-13) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PDGF-C Antibody (KJ-13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDGF-C Antibody (KJ-13) Specifications

Alternate Product Name: PDGF-C

Product Clone Name: KJ-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 230-345

Epitope Target: PDGF-C

Epitope Species: mouse

Product Reactivity/Detection: PDGF-C

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PDGF-C Antibody (KJ-13): N/A