PDE6D Antibody (E-8): sc-166836
- PDE6D Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-150 representing full length PDE6D of human origin
- recommended for detection of PDE6D of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PDE6D Antibody (E-8) for WB applications. These reagents are now offered in bundles with PDE6D Antibody (E-8) (see ordering information below).
PDE6D Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects phosphodiesterase 6D in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE6D plays a crucial role in the visual signaling pathway, specifically in the phototransduction process within the retina, where PDE6D regulates the levels of cyclic guanosine monophosphate (cGMP) by hydrolyzing it to 5′GMP. This regulation is vital for maintaining the proper function of photoreceptor cells, as fluctuations in cGMP levels can significantly impact visual signal transduction and overall retinal health. PDE6D is a retina-specific oligomer composed of two catalytic chains (α and β), an inhibitory chain (γ), and the δ chain, which together ensure precise control over cGMP levels. Notably, PDE6D interacts with proteins such as RPGR, ARL2, and ARL3, which are essential for PDE6D function and stability. Additionally, PDE6D contains two N-linked glycosylation sites, which are important for proper folding and activity, further underscoring the significance of post-translational modifications in the regulation of this critical enzyme. Anti-PDE6D antibody (E-8) is an invaluable tool for researchers studying retinal function and related disorders, providing reliable detection and characterization of this important protein.
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PDE6D Antibody (E-8) References:
- Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). | Wang, W., et al. 1999. Gene. 236: 325-32. PMID: 10452952
- ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting. | Humbert, MC., et al. 2012. Proc Natl Acad Sci U S A. 109: 19691-6. PMID: 23150559
- PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner. | Lee, JJ. and Seo, S. 2015. EMBO Rep. 16: 1581-2. PMID: 26553938
- The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression. | Dietrich, P., et al. 2019. Cancers (Basel). 11: PMID: 30901922
- PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity. | Siddiqui, FA., et al. 2020. ACS Omega. 5: 832-842. PMID: 31956834
- Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. | Teng, M., et al. 2022. J Med Chem. 65: 747-756. PMID: 34965125
- Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. | Canovas Nunes, S., et al. 2022. Blood Cancer J. 12: 64. PMID: 35422065
- PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia. | Faber, S., et al. 2023. Cells. 12: PMID: 36672247
- An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth. | Kaya, P., et al. 2024. J Med Chem. 67: 8569-8584. PMID: 38758695
- Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. | Li, N., et al. 1998. Genomics. 49: 76-82. PMID: 9570951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDE6D Antibody (E-8) | sc-166836 | 200 µg/ml | $316.00 | |||
PDE6D Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-540167 | 200 µg Ab; 10 µg BP | $354.00 | |||
PDE6D Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-541945 | 200 µg Ab; 20 µg BP | $354.00 |