PDE3B Antibody (F-9): sc-376823

PDE3B Antibody (F-9) is a mouse monoclonal IgM antibody that detects PDE3B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-PDE3B antibody (F-9) is available as a non-conjugated monoclonal isotype antibody. PDE3B plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a vital second messenger involved in various cellular processes, including lipolysis and insulin signaling. By hydrolyzing cAMP to 5′AMP, PDE3B helps modulate signaling pathways that are essential for maintaining cardiovascular health and metabolic functions. Notably, PDE3B is predominantly expressed in lymphocytes and adipose tissue, where PDE3B contributes to the regulation of energy homeostasis and immune responses. The importance of PDE3B in these tissues underscores PDE3B′s potential as a therapeutic target for conditions such as obesity and cardiovascular diseases, making PDE3B (F-9) antibody a valuable tool for researchers investigating these critical biological processes.

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PDE3B Antibody (F-9) References:

1. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.  |  Hetman, JM., et al. 2000. Proc Natl Acad Sci U S A. 97: 472-6. PMID: 10618442
2. Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.  |  Kasuya, J., et al. 2000. Biochem Biophys Res Commun. 268: 827-34. PMID: 10679291
3. From PDE3B to the regulation of energy homeostasis.  |  Degerman, E., et al. 2011. Curr Opin Pharmacol. 11: 676-82. PMID: 22001403
4. CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma.  |  Yue, W., et al. 2023. Histol Histopathol. 38: 1029-1041. PMID: 36533720
5. Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.  |  Chen, L., et al. 2024. Int J Nanomedicine. 19: 4411-4427. PMID: 38774028
6. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants.  |  Bloom, TJ. and Beavo, JA. 1996. Proc Natl Acad Sci U S A. 93: 14188-92. PMID: 8943082
7. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.  |  Han, P., et al. 1997. J Biol Chem. 272: 16152-7. PMID: 9195912
8. Cyclic AMP phosphodiesterases in human lymphocytes.  |  Sheth, SB., et al. 1997. Br J Haematol. 99: 784-9. PMID: 9432022
9. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.  |  Gantner, F., et al. 1998. Br J Pharmacol. 123: 1031-8. PMID: 9559883
10. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.  |  Fisher, DA., et al. 1998. Biochem Biophys Res Commun. 246: 570-7. PMID: 9618252
11. Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.  |  Cheung, PP., et al. 1998. Arch Biochem Biophys. 360: 99-104. PMID: 9826434
12. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP.  |  Liu, H. and Maurice, DH. 1998. Br J Pharmacol. 125: 1501-10. PMID: 9884079

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDE3B Antibody (F-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PDE3B Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDE3B Antibody (F-9) Specifications

Alternate Product Name: PDE3B

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2-29

Epitope Target: PDE3B

Epitope Species: human

Product Reactivity/Detection: PDE3B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PDE3B Antibody (F-9): P: Blocking Peptide