PDE1C Antibody (G-3): sc-137251

PDE1C Antibody (G-3) is a mouse monoclonal IgG2a antibody that detects phosphodiesterase 1C (PDE1C) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE1C is a crucial enzyme in the regulation of intracellular signaling, specifically in the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are vital second messengers involved in numerous physiological processes such as cardiac function, neuronal signaling, and smooth muscle contraction. Anti-PDE1C antibody (G-3) helps researchers study how PDE1C modulates cyclic nucleotide levels, influencing various signaling pathways that affect cellular responses to external stimuli. Notably, PDE1C exists in two isoforms, PDE1C1 and PDE1C2, which arise from alternative splicing and exhibit distinct expression patterns; while both isoforms are present at low levels throughout the body, PDE1C2 is predominantly found in the brain and heart, whereas PDE1C1 is more widely expressed in the brain, heart, and lung. The differential expression of these isoforms suggests that PDE1C may play specialized roles in different tissues, making PDE1C (G-3) antibody an essential tool for research into therapeutic interventions for conditions such as heart disease and neurological disorders.

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PDE1C Antibody (G-3) References:

1. The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion.  |  Han, P., et al. 1999. J Biol Chem. 274: 22337-44. PMID: 10428803
2. Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.  |  Rowther, FB., et al. 2016. Mol Carcinog. 55: 268-79. PMID: 25620587
3. PDE1C negatively regulates growth factor receptor degradation and promotes VSMC proliferation.  |  Satoh, K., et al. 2015. Circ Res. 116: 1098-100. PMID: 25814676
4. PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.  |  Knight, WE., et al. 2016. Proc Natl Acad Sci U S A. 113: E7116-E7125. PMID: 27791092
5. Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival.  |  Zhang, Y., et al. 2018. Circulation. 138: 1988-2002. PMID: 29871977
6. Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα.  |  Shete, V., et al. 2018. Int J Mol Sci. 19: PMID: 30469494
7. An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells.  |  Brzezinska, P. and Maurice, DH. 2019. Cells. 8: PMID: 31757003
8. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics.  |  Rexach, JE., et al. 2024. Cell. 187: 5753-5774.e28. PMID: 39265576
9. Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1β-induced apoptosis, inflammation and oxidative stress in human chondrocytes.  |  Gao, L., et al. 2024. Adv Rheumatol. 64: 92. PMID: 39736775
10. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.  |  Yan, C., et al. 1996. J Biol Chem. 271: 25699-706. PMID: 8810348

The preferred PDE1C antibody is PDE1C Antibody (G-7): sc-376474.