Pdcd-4 Antibody (k4C1): sc-130545
- Pdcd-4 Antibody (k4C1) is a mouse monoclonal IgG1, cited in 13 publications, provided at 50 µg/0.5 ml
- raised against full-length recombinant Pdcd-4 of human origin
- recommended for detection of Pdcd-4 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pdcd-4 Antibody (k4C1). This work is in progress.
Pdcd-4 Antibody (k4C1) is a mouse monoclonal IgG1 antibody that detects Pdcd-4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Pdcd-4, or programmed cell death gene 4, plays a crucial role in regulating protein translation and is recognized for its potential as a tumor suppressor gene, particularly in the context of human lung cancer. Anti-Pdcd-4 antibody (k4C1) targets a protein primarily located in the cytoplasm and nucleus, where Pdcd-4 exerts effects on cellular processes. Pdcd-4′s ability to inhibit the activity of c-Jun, a key transcription factor involved in cell proliferation and survival, underscores Pdcd-4′s importance in cancer biology. By blocking the recruitment of the co-activator p300 and interfering with the assembly of the cap-dependent translation initiation complex, Pdcd-4 effectively suppresses the transactivation of AP-1 responsive promoters, thereby contributing to tumor-suppressive functions. Pdcd-4 (k4C1) antibody serves as an essential tool for researchers investigating the mechanisms of tumorigenesis and the regulatory pathways involved in cell death and survival.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Pdcd-4 Antibody (k4C1) References:
- DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation. | Cui, H., et al. 2019. J Exp Clin Cancer Res. 38: 350. PMID: 31409387
- Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis. | Gao, G., et al. 2019. Artif Cells Nanomed Biotechnol. 47: 3839-3846. PMID: 31556312
- PDCD4 limits prooncogenic neuregulin-ErbB signaling. | Montero, JC. and Pandiella, A. 2021. Cell Mol Life Sci. 78: 1799-1815. PMID: 32804243
- MicroRNA-16, Programmed Cell Death Protein-4 (PDCD-4) and Polycystic Ovarian Syndrome. | Zehra, N., et al. 2020. J Coll Physicians Surg Pak. 30: 880-881. PMID: 32893806
- Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis. | Yu, Q., et al. 2021. Int J Mol Med. 47: PMID: 33786608
- Dissecting the Roles of PDCD4 in Breast Cancer. | Cai, Q., et al. 2022. Front Oncol. 12: 855807. PMID: 35795053
- PDCD4 restricts PRRSV replication in an eIF4A-dependent manner and is antagonized by the viral nonstructural protein 9. | Wei, R., et al. 2024. J Virol. 98: e0006024. PMID: 38557170
- Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. | Ye, X., et al. 2024. Cell Res. 34: 522-525. PMID: 38641729
- Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling. | Li, Y., et al. 2024. J Neuroinflammation. 21: 143. PMID: 38822367
- PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression. | Lu, K., et al. 2024. Metabolism. 161: 156036. PMID: 39342987
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pdcd-4 Antibody (k4C1) | sc-130545 | 50 µg/0.5 ml | $322.00 |