CD274/PD-L1 Antibody (1C10): sc-293425

Pdcd-1L1 Antibody (1C10) is a mouse monoclonal IgG2b kappa light chain antibody that detects Pdcd-1L1 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pdcd-1L1 antibody (1C10) is available as a non-conjugated format. Pdcd-1L1, also known as programmed cell death ligand-1, B7-H1, or PD-L1, is a crucial type I transmembrane protein composed of 290 amino acids, which plays a significant role in immune regulation by interacting with the PD-1 receptor on T cells, thereby inhibiting T cell activation and promoting immune tolerance. This interaction is particularly important in cancer, as many tumors exploit the PD-1/PD-L1 pathway to evade immune detection, making Pdcd-1L1 a key target for immunotherapy. Structurally, Pdcd-1L1 features immunoglobulin V-like and C-like domains along with a 30 amino acid cytoplasmic tail, which is essential for signaling capabilities. The gene encoding Pdcd-1L1 is located on human chromosome 9p24, and expression is constitutive in various tissues, including heart, lung, and kidney, suggesting a role in maintaining immune homeostasis and preventing autoimmune diseases. Using Pdcd-1L1 monoclonal antibody (1C10) in research can provide valuable insights into immune regulation mechanisms and potential therapeutic applications for cancer treatment.

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CD274/PD-L1 Antibody (1C10) References:

1. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.  |  Dong, H., et al. 1999. Nat Med. 5: 1365-9. PMID: 10581077
2. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.  |  Freeman, GJ., et al. 2000. J Exp Med. 192: 1027-34. PMID: 11015443
3. PD-L2 is a second ligand for PD-1 and inhibits T cell activation.  |  Latchman, Y., et al. 2001. Nat Immunol. 2: 261-8. PMID: 11224527
4. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.  |  Nishimura, H. and Honjo, T. 2001. Trends Immunol. 22: 265-8. PMID: 11323285

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD274/PD-L1 Antibody (1C10) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-CD274/PD-L1 Antibody (1C10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD274/PD-L1 Antibody (1C10) Specifications

Alternate Product Name: PD-L1

Product Clone Name: 1C10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 18-238

Epitope Target: PD-L1

Epitope Species: human

Product Reactivity/Detection: PD-L1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for CD274/PD-L1 Antibody (1C10): N/A

The preferred CD274/PD-L1 antibody is CD274/PD-L1 Antibody (D-8): sc-518027.