Pbx 3 Antibody (39-K): sc-81988
- Pbx 3 Antibody (39-K) is a mouse monoclonal mouse IgG2a κ κ provided at 100 µg/ml
- raised against recombinant Pbx 3 of human origin
- recommended for detection of Pbx 3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pbx 3 Antibody (39-K). This work is in progress.
Pbx 3 Antibody (39-K) is a mouse monoclonal IgG2a light chain antibody that detects Pbx 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Pbx 3, a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, plays a crucial role in regulating gene expression during development and differentiation. Anti-Pbx 3 antibody (39-K) forms heterodimers with other homeodomain proteins to influence various developmental processes, making Pbx 3 essential for proper cellular function and tissue formation. Notably, Pbx 3 is involved in the regulation of hematopoiesis and has been implicated in the pathogenesis of certain leukemias, particularly due to its association with chromosomal rearrangements that lead to oncogenic fusion proteins. Pbx 3 expression spans both fetal and adult tissues, highlighting its importance in maintaining cellular homeostasis. Additionally, Pbx 3 interacts with other proteins, such as the E2A gene products, which further underscores its significance in transcriptional regulation and cellular signaling pathways. Pbx 3 monoclonal antibody (39-K) serves as an invaluable tool for researchers studying the intricate roles of Pbx proteins in health and disease.
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Pbx 3 Antibody (39-K) References:
- Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia. | Garcia-Cuellar, MP., et al. 2015. Haematologica. 100: 905-13. PMID: 25911551
- PBX3 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition. | Wang, S., et al. 2016. Oncol Lett. 12: 3485-3491. PMID: 27900025
- PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. | Guo, H., et al. 2017. Int J Cancer. 141: 324-335. PMID: 28411381
- PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer. | Li, H., et al. 2017. Onco Targets Ther. 10: 5685-5694. PMID: 29225475
- PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion. | Xu, X., et al. 2018. J Exp Clin Cancer Res. 37: 158. PMID: 30016974
- PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma. | Chen, Q., et al. 2020. Biomed Res Int. 2020: 8954513. PMID: 32047817
- SNHG10/DDX54/PBX3 Feedback Loop Contributes to Gastric Cancer Cell Growth. | Zhang, Y., et al. 2021. Dig Dis Sci. 66: 1875-1884. PMID: 32712782
- P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways. | He, X., et al. 2023. Leukemia. 37: 265-275. PMID: 36418376
- PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression. | Luo, X., et al. 2023. Int J Biol Sci. 19: 4525-4538. PMID: 37781025
- PBX3 as a biomarker for the early diagnosis and prediction of prognosis of glioma. | Pan, C., et al. 2024. PLoS One. 19: e0293647. PMID: 38324550
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pbx 3 Antibody (39-K) | sc-81988 | 100 µg/ml | $322.00 |