PBGS Antibody (G-9): sc-365095

PBGS Antibody (G-9) is a mouse monoclonal IgG2a antibody that detects porphobilinogen synthase (PGBS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PGBS antibody (G-9) recognizes PGBS, an essential enzyme in the heme biosynthetic pathway, which plays a critical role in the synthesis of heme, cytochromes, and other hemoproteins. PGBS (G-9) antibody targets PGBS, which is composed of eight identical subunits, allowing efficient catalysis of the condensation of two molecules of δ-aminolevulinate to form porphobilinogen. This structural arrangement enhances enzyme stability and catalytic efficiency, making PGBS vital for maintaining proper heme levels in the body. Disruptions in PGBS function can lead to serious health issues, including increased sensitivity to lead poisoning and various forms of acute hepatic porphyria, highlighting PGBS importance in both metabolic processes and toxicology. PGBS monoclonal antibody (G-9) serves as an invaluable tool for researchers studying PGBS role in these critical biological pathways and its implications in disease.

The preferred PBGS antibody is PBGS Antibody (A-7): sc-271585.