Pax-9 Antibody (7C2): sc-56823
- Pax-9 Antibody (7C2) is a rat monoclonal IgG1 Pax-9 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against recombinant Pax-9 fusion protein of mouse origin
- Pax-9 Antibody (7C2) is recommended for detection of Pax-9 of mouse, rat and human origin by WB, IP, IF and IHC(P); non cross-reactive with other Pax proteins
- Anti-Pax-9 Antibody (7C2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pax-9 Antibody (7C2). This work is in progress.
Pax-9 Antibody (7C2) is a rat monoclonal IgG1 antibody that detects Pax-9 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Pax-9 (7C2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pax-9 plays a crucial role in the development of various organs and skeletal elements, making Pax-9 essential for proper embryonic development. Pax-9 is a member of the paired box gene family, which is characterized by its paired domain that shares strong homology with genes in Drosophila, known for their involvement in early developmental programming. The importance of Pax-9 is underscored by associations with several inherited skeletal disorders; mutations in Pax-9 can lead to conditions such as Jarcho-Levin syndrome and other forms of spondylocostal dysplasia, which are characterized by abnormal vertebral development. Notably, a frameshift mutation within the paired domain of Pax-9 has been linked to autosomal dominant oligodontia, a condition where individuals have normal primary teeth but are missing most permanent molars, along with potential absence of other teeth. Pax-9 is located on human chromosome 14q12-q13, highlighting Pax-9′s significance in genetic studies related to dental and skeletal anomalies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Pax-9 Antibody (7C2) References:
- Expression of the paired-box genes Pax-1 and Pax-9 in limb skeleton development. | LeClair, EE., et al. 1999. Dev Dyn. 214: 101-15. PMID: 10030590
- Mutation of PAX9 is associated with oligodontia. | Stockton, DW., et al. 2000. Nat Genet. 24: 18-9. PMID: 10615120
- Association between PAX-9 promoter polymorphisms and hypodontia in humans. | Peres, RC., et al. 2005. Arch Oral Biol. 50: 861-71. PMID: 16137495
- Dual odontogenic origins develop at the early stage of rat maxillary incisor development. | Kriangkrai, R., et al. 2006. Anat Embryol (Berl). 211: 101-8. PMID: 16416307
- New syndromic form of benign hereditary chorea is associated with a deletion of TITF-1 and PAX-9 contiguous genes. | Devos, D., et al. 2006. Mov Disord. 21: 2237-40. PMID: 17044090
- Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. | Stapleton, P., et al. 1993. Nat Genet. 3: 292-8. PMID: 7981748
- A new Pax gene, Pax-9, maps to mouse chromosome 12. | Wallin, J., et al. 1993. Mamm Genome. 4: 354-8. PMID: 8358169
- Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. | Peters, H., et al. 1998. Genes Dev. 12: 2735-47. PMID: 9732271
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pax-9 Antibody (7C2) | sc-56823 | 200 µg/ml | $316.00 | |||
Pax-9 Antibody (7C2) AC | sc-56823 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Pax-9 Antibody (7C2) HRP | sc-56823 HRP | 200 µg/ml | $316.00 | |||
Pax-9 Antibody (7C2) FITC | sc-56823 FITC | 200 µg/ml | $330.00 | |||
Pax-9 Antibody (7C2) PE | sc-56823 PE | 200 µg/ml | $343.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 488 | sc-56823 AF488 | 200 µg/ml | $357.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 546 | sc-56823 AF546 | 200 µg/ml | $357.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 594 | sc-56823 AF594 | 200 µg/ml | $357.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 647 | sc-56823 AF647 | 200 µg/ml | $357.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 680 | sc-56823 AF680 | 200 µg/ml | $357.00 | |||
Pax-9 Antibody (7C2) Alexa Fluor® 790 | sc-56823 AF790 | 200 µg/ml | $357.00 |