PATZ1 Antibody (H-2): sc-393223
- PATZ1 Antibody (H-2) is a mouse monoclonal IgG3 κ PATZ1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of PATZ1 of human origin
- PATZ1 Antibody (H-2) is recommended for detection of PATZ1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-PATZ1 Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-393223 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PATZ1 Antibody (H-2) for WB applications. This reagent is now offered in a bundle with PATZ1 Antibody (H-2) (see ordering information below).
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PATZ1 Antibody (H-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects PATZ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PATZ1 (H-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PATZ1 protein, also known as POZ (BTB) and AT hook containing zinc finger 1, is a 687 amino acid nuclear protein that plays a crucial role in transcriptional regulation. PATZ1 contains one A.T hook DNA-binding domain, one BTB (POZ) domain, and seven C2H2-type zinc fingers, which are essential for function in gene expression modulation. The presence of zinc-finger motifs allows PATZ1 to interact with specific DNA sequences, thereby influencing transcription of target genes. This interaction is vital for cellular processes, including differentiation and development, and dysregulation of PATZ1 has been implicated in pathogenesis of various cancers, such as small round cell sarcoma and colorectal cancer. Additionally, multiple isoforms of PATZ1 arise from alternative splicing, which may contribute to functional diversity and regulatory mechanisms within cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PATZ1 Antibody (H-2) References:
- A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. | Kobayashi, A., et al. 2000. Mol Cell Biol. 20: 1733-46. PMID: 10669750
- A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. | Fedele, M., et al. 2000. J Biol Chem. 275: 7894-901. PMID: 10713105
- A novel zinc finger gene is fused to EWS in small round cell tumor. | Mastrangelo, T., et al. 2000. Oncogene. 19: 3799-804. PMID: 10949935
- PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. | Pero, R., et al. 2002. J Biol Chem. 277: 3280-5. PMID: 11719514
- Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. | Bilic, I., et al. 2006. Nat Immunol. 7: 392-400. PMID: 16491076
- PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. | Fedele, M., et al. 2008. J Pathol. 215: 39-47. PMID: 18241078
- Zinc finger protein 278, a potential oncogene in human colorectal cancer. | Tian, X., et al. 2008. Acta Biochim Biophys Sin (Shanghai). 40: 289-96. PMID: 18401526
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PATZ1 Antibody (H-2) | sc-393223 | 200 µg/ml | $322.00 | |||
PATZ1 Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-526228 | 200 µg Ab; 10 µg BP | $361.00 | |||
PATZ1 Antibody (H-2) X | sc-393223 X | 200 µg/0.1 ml | $322.00 | |||
PATZ1 Antibody (H-2) AC | sc-393223 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PATZ1 Antibody (H-2) HRP | sc-393223 HRP | 200 µg/ml | $322.00 | |||
PATZ1 Antibody (H-2) FITC | sc-393223 FITC | 200 µg/ml | $336.00 | |||
PATZ1 Antibody (H-2) PE | sc-393223 PE | 200 µg/ml | $349.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 488 | sc-393223 AF488 | 200 µg/ml | $364.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 546 | sc-393223 AF546 | 200 µg/ml | $364.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 594 | sc-393223 AF594 | 200 µg/ml | $364.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 647 | sc-393223 AF647 | 200 µg/ml | $364.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 680 | sc-393223 AF680 | 200 µg/ml | $364.00 | |||
PATZ1 Antibody (H-2) Alexa Fluor® 790 | sc-393223 AF790 | 200 µg/ml | $364.00 |