patched/PTCH1 Antibody (3B3): sc-293416
- patched/PTCH1 Antibody (3B3) is a mouse monoclonal IgG2a κ patched/PTCH1 antibody, cited in 5 publications, provided at 100 µg/ml
- raised against a full length recombinant protein representing amino acids 651-750 of patched of human origin
- recommended for detection of patched of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for patched/PTCH1 Antibody (3B3). This work is in progress.
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Patched Antibody (3B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects patched protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-patched antibody (3B3) is available as a non-conjugated format. Patched protein, also known as PTCH1, plays a crucial role in the hedgehog signaling pathway, which regulates cell growth and differentiation during embryonic development. This pathway is vital for proper tissue patterning and organogenesis, and dysregulation can lead to severe developmental disorders and various cancers. PTCH1 (3B3) antibody functions as a receptor that inhibits hedgehog protein activity, thereby controlling expression of downstream target genes involved in cell proliferation and survival. When mutations occur in PTCH1, unregulated hedgehog signaling can develop, which is associated with basal cell carcinoma, the most common skin cancer in the United States, affecting approximately 750,000 individuals annually. The interaction between patched and other proteins in the hedgehog pathway, such as Sonic hedgehog and GLI transcription factors, underscores PTCH1′s importance in maintaining cellular homeostasis and potential as a therapeutic target in cancer treatment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
patched/PTCH1 Antibody (3B3) | sc-293416 | 100 µg/ml | $322.00 |