Parafibromin Antibody (G-11): sc-365053

Parafibromin Antibody (G-11) is a mouse monoclonal IgG3 antibody that detects Parafibromin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Parafibromin plays a critical role as a tumor suppressor, encoded by the CDC73 gene, which is essential for regulating cell division and maintaining genomic stability. Parafibromin is located in the nucleus, where anti-Parafibromin antibody (G-11) identifies a key component of the RNA polymerase II/Paf1 complex, facilitating transcriptional regulation of genes through histone modification. Proper functioning of Parafibromin is vital, as dysregulation can lead to the development of parathyroid tumors and other endocrine disorders. Parafibromin interacts with various proteins involved in transcriptional regulation and chromatin remodeling, underscoring its importance in cellular processes. Parafibromin monoclonal antibody (G-11) is an invaluable tool for researchers studying parathyroid carcinoma and related conditions, providing insights into the molecular mechanisms underlying these diseases.

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Parafibromin Antibody (G-11) References:

1. The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.  |  Yang, YJ., et al. 2010. Nucleic Acids Res. 38: 382-90. PMID: 19906718
2. SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.  |  Takahashi, A., et al. 2011. Mol Cell. 43: 45-56. PMID: 21726809
3. Expression of parafibromin in clear cell papillary renal cell carcinoma.  |  Cui, C., et al. 2013. Appl Immunohistochem Mol Morphol. 21: 322-5. PMID: 23060304
4. CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer.  |  Cetani, F., et al. 2013. Endocr Connect. 2: 186-95. PMID: 24145611
5. The clinicopathological significances and biological functions of parafibromin expression in head and neck squamous cell carcinomas.  |  Zhang, Z., et al. 2015. Tumour Biol. 36: 9487-97. PMID: 26124004
6. The roles of parafibromin expression in ovarian epithelial carcinomas: a marker for differentiation and prognosis and a target for gene therapy.  |  Shen, DF., et al. 2016. Tumour Biol. 37: 2909-24. PMID: 26409451
7. The Role of Parafibromin, Galectin-3, HBME-1, 
and Ki-67 in the Differential Diagnosis of Parathyroid Tumors.  |  Karaarslan, S., et al. 2015. Oman Med J. 30: 421-7. PMID: 26675091
8. The Relation of Parafibromin Expression with Clinicopathological Factors in Invasive Breast Carcinomas.  |  Karaarslan, S., et al. 2016. Turk Patoloji Derg. 32: 8-14. PMID: 26832176
9. Parafibromin, APC, and MIB-1 Are Useful Markers for Distinguishing Parathyroid Carcinomas From Adenomas.  |  Hosny Mohammed, K., et al. 2017. Appl Immunohistochem Mol Morphol. 25: 731-735. PMID: 27490759
10. Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin.  |  Tang, C., et al. 2018. iScience. 1: 1-15. PMID: 30227954

The preferred Parafibromin antibody is Parafibromin Antibody (2H1): sc-33638.