Pannexin-1 Antibody (2E3): sc-293210
- Pannexin-1 Antibody (2E3) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against amino acids 327-425 of Pannexin-1 of human origin
- recommended for detection of Pannexin-1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pannexin-1 Antibody (2E3). This work is in progress.
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Pannexin-1 Antibody (2E3) is a mouse monoclonal IgG2a antibody that detects Pannexin-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Pannexin-1 plays a crucial role as a transmembrane protein that forms calcium-permeable gap junctions, facilitating intercellular communication and maintaining cellular homeostasis. Anti-Pannexin-1 antibody (2E3) recognizes channels that allow the passage of ions and small molecules vital for various physiological processes, including the regulation of inflammation and cell signaling. Notably, Pannexin-1 is also involved in the formation of mechanosensitive ATP-permeable channels in erythrocytes, which are essential for responding to mechanical stress and maintaining energy homeostasis. The expression of Pannexin-1 is particularly important in excitable tissues, where Pannexin-1 contributes to electrical conduction and the coordination of cellular responses. Dysregulation of Pannexin-1 has been associated with various pathological conditions, including cancer, where decreased expression can lead to impaired gap junction communication and altered cell growth. With a significant role in cellular communication and function, Pannexin-1 monoclonal antibody (2E3) serves as an invaluable tool for researchers investigating the complexities of cell signaling and the implications of Pannexin-1 in health and disease.
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Pannexin-1 Antibody (2E3) References:
- Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage. | Cisneros-Mejorado, A., et al. 2015. J Cereb Blood Flow Metab. 35: 843-50. PMID: 25605289
- Pannexin-1 channels in epilepsy. | Aquilino, MS., et al. 2019. Neurosci Lett. 695: 71-75. PMID: 28886985
- Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. | Chen, KW., et al. 2020. Eur J Immunol. 50: 170-177. PMID: 31411729
- Pannexin-1 Channel Regulates ATP Release in Epilepsy. | Shan, Y., et al. 2020. Neurochem Res. 45: 965-971. PMID: 32170674
- Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis. | Huang, G., et al. 2020. Life Sci. 254: 117791. PMID: 32416166
- Pannexin-1 Channels as Mediators of Neuroinflammation. | Seo, JH., et al. 2021. Int J Mol Sci. 22: PMID: 34068881
- Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation. | Filiberto, AC., et al. 2022. Nat Commun. 13: 1521. PMID: 35315432
- The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis. | Hernandez, CA. and Eliseo, E. 2022. Cells. 11: PMID: 35883688
- Pannexin 1 targets mitophagy to mediate renal ischemia/reperfusion injury. | Su, L., et al. 2023. Commun Biol. 6: 889. PMID: 37644178
- Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts. | Weilinger, NL., et al. 2023. Cell Rep. 42: 113128. PMID: 37742194
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pannexin-1 Antibody (2E3) | sc-293210 | 100 µg/ml | $322.00 |