PANK3 Antibody (MDA-299-62A): sc-551231

PANK3 Antibody (MDA-299-62A) is a mouse monoclonal IgG2a antibody that detects PANK3 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PANK3 (MDA-299-62A) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The pantothenate kinase (PANK) family, to which PANK3 belongs, is crucial for catalyzing the initial step in the biosynthesis of coenzyme A (CoA), a vital coenzyme that plays a significant role in the synthesis and oxidation of fatty acids, as well as in the oxidation of pyruvate during the citric acid (Krebs) cycle. PANK3, a 370 amino acid protein, is primarily localized in the cytoplasm and is essential for the physiological regulation of intracellular CoA concentrations. PANK3 is subject to feedback inhibition by CoA and its thioesters, which ensures that cellular levels of CoA remain balanced. PANK3 catalyzes the phosphorylation of pantothenate (Vitamin B5) using ATP, resulting in the formation of 4′-phosphopantothenate, a critical intermediate in CoA biosynthesis. Notably, PANK3 is closely related to other family members, including PANK1, PANK2, and PANK4, and is highly expressed in the liver. Mutations in the gene encoding PANK2, the only mitochondria-targeted human PANK, are associated with pantothenate kinase-associated neurodegeneration (PKAN), highlighting the importance of PANK family proteins in human health.

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PANK3 Antibody (MDA-299-62A) References:

1. Pantothenate kinase regulation of the intracellular concentration of coenzyme A.  |  Rock, CO., et al. 2000. J Biol Chem. 275: 1377-83. PMID: 10625688
2. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.  |  Zhou, B., et al. 2001. Nat Genet. 28: 345-9. PMID: 11479594
3. Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome).  |  Gordon, N. 2002. Eur J Paediatr Neurol. 6: 243-7. PMID: 12374576
4. Coenzyme A: back in action.  |  Leonardi, R., et al. 2005. Prog Lipid Res. 44: 125-53. PMID: 15893380
5. Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.  |  Zhang, YM., et al. 2005. J Biol Chem. 280: 32594-601. PMID: 16040613
6. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.  |  Hong, BS., et al. 2007. J Biol Chem. 282: 27984-93. PMID: 17631502
7. Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.  |  Wu, Z., et al. 2009. Hum Mol Genet. 18: 3659-72. PMID: 19602483

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PANK3 Antibody (MDA-299-62A) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PANK3 Antibody (MDA-299-62A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PANK3 Antibody (MDA-299-62A) Specifications

Alternate Product Name: PANK3

Product Clone Name: MDA-299-62A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-370

Epitope Target: PANK3

Epitope Species: human

Product Reactivity/Detection: PANK3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PANK3 Antibody (MDA-299-62A): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin