Pancreatic Polypeptide Antibody (B-2): sc-514155

Pancreatic Polypeptide Antibody (B-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects Pancreatic Polypeptide (PP) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PP antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PP is primarily located in the endocrine F-cells of the pancreatic islets, where PP plays a crucial role in regulating energy homeostasis and appetite. Upon food intake, PP is secreted into the bloodstream, where PP acts as an anorexigenic hormone, signaling satiety and helping to modulate food intake. This localization enables rapid hormonal responses to changes in nutrient availability, thereby influencing metabolic processes. Notably, individuals with Prader-Willi syndrome exhibit a diminished PP response to meals, highlighting PP′s importance in appetite regulation. Furthermore, PP administration has been explored as a potential therapeutic strategy for obesity, as PP can effectively decrease food consumption.

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Pancreatic Polypeptide Antibody (B-2) References:

1. Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects.  |  Koska, J., et al. 2004. Diabetes. 53: 3091-6. PMID: 15561938
2. A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control.  |  Schmidt, PT., et al. 2005. J Clin Endocrinol Metab. 90: 5241-6. PMID: 15998783
3. Differentiation of adult hepatic stem-like cells into pancreatic endocrine cells.  |  Yamada, S., et al. 2005. Cell Transplant. 14: 647-53. PMID: 16405075
4. Multihormonality and entrapment of islets in pancreatic endocrine tumors.  |  Kapran, Y., et al. 2006. Virchows Arch. 448: 394-8. PMID: 16418841
5. The regional distribution and relative frequency of gastrointestinal endocrine cells in the nude mice, Balb/c-nu/nu: an immunohistochemical study.  |  Ku, SK., et al. 2006. Anat Histol Embryol. 35: 104-10. PMID: 16542175
6. Exons of the human pancreatic polypeptide gene define functional domains of the precursor.  |  Leiter, AB., et al. 1985. J Biol Chem. 260: 13013-7. PMID: 2997153
7. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.  |  Takeuchi, T., et al. 1986. J Clin Invest. 77: 1038-41. PMID: 3753985
8. Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor.  |  Schwartz, TW., et al. 1984. Proc Natl Acad Sci U S A. 81: 708-12. PMID: 6366786
9. A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide.  |  Boel, E., et al. 1984. EMBO J. 3: 909-12. PMID: 6373251

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pancreatic Polypeptide Antibody (B-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Pancreatic Polypeptide Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pancreatic Polypeptide Antibody (B-2) Specifications

Alternate Product Name: Pancreatic Polypeptide

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-95

Epitope Target: pancreatic prohormone precursor

Epitope Species: human

Product Reactivity/Detection: Pancreatic Polypeptide and Pancreatic Prohormone Precursor

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Pancreatic Polypeptide Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin