pan ET Antibody (3G10): sc-57396

pan ET Antibody (3G10) is a rat monoclonal IgG2b antibody that detects endothelin (ET) of human origin by immunofluorescence (IF). anti-ET antibody (3G10) is available as the non-conjugated form, providing versatile applications in research. Endothelins are critical peptides that play a significant role in regulating vascular tone and blood pressure, exhibiting strong constrictor activity on both vascular and non-vascular smooth muscle. Endothelins influence neuronal excitability and can affect the central nervous system, highlighting their multifaceted roles in both cardiovascular and neurological functions. The three isoforms of endothelin—ET-1, ET-2, and ET-3—are produced from larger precursors through the action of endothelin-converting enzymes, with ET-1 being particularly notable for its potent vasoconstrictive properties. The genes encoding these isoforms are located on different chromosomes, with ET-1, 2, and 3 mapping to chromosomes 6p23-p24, 1p34, and 20q13.2-q13.3, respectively. Among these, ET-2 is recognized for having the most potent vasoconstrictor activity, making the study of endothelins essential for understanding various physiological and pathological processes. ET monoclonal antibody (3G10) provides a valuable tool for researchers investigating the diverse roles of endothelins in health and disease.

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pan ET Antibody (3G10) References:

1. The role of endothelins and their receptors in heart failure.  |  Giannessi, D., et al. 2001. Pharmacol Res. 43: 111-26. PMID: 11243712
2. Identification and partial purification of a thiol endothelin-converting enzyme from porcine aortic endothelial cells.  |  Deng, Y., et al. 1992. J Biochem. 111: 346-51. PMID: 1587796
3. Endothelins.  |  Rubanyi, GM. and Botelho, LH. 1991. FASEB J. 5: 2713-20. PMID: 1916094
4. Federation of American Societies for Experimental Biology. 75th Annual Meeting. Atlanta, Georgia, April 21-25, 1991. Part I. Abstracts.  |  . 1991. FASEB J. 5: A371-915. PMID: 1997360
5. Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.  |  Arinami, T., et al. 1991. Am J Hum Genet. 48: 990-6. PMID: 2018043
6. The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.  |  Inoue, A., et al. 1989. J Biol Chem. 264: 14954-9. PMID: 2670930
7. The role of endothelin in heart failure and hypertension.  |  Nguyen, BN. and Johnson, JA. 1998. Pharmacotherapy. 18: 706-19. PMID: 9692645

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan ET Antibody (3G10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-pan ET Antibody (3G10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan ET Antibody (3G10) Specifications

Alternate Product Name: pan ET

Product Clone Name: 3G10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: pan ET

Epitope Species: human

Product Reactivity/Detection: C-terminal region of all endothelins (amino acid residues 15-21)

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for pan ET Antibody (3G10): N/A