PAI-1/SERPINE1 Antibody (3A120): sc-59633
- PAI-1/SERPINE1 Antibody (3A120) is a mouse monoclonal IgG, cited in 7 publications, provided at 100 µg/ml
- raised against full length PAI-1 of human origin
- recommended for detection of both free and complexed forms of PAI-1 of human origin by WB, IP and ELISA
- See PAI-1/SERPINE1 (C-9): sc-5297 for PAI-1/SERPINE1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PAI-1/SERPINE1 Antibody (3A120). This work is in progress.
PAI-1 Antibody (3A120) is a mouse monoclonal IgG antibody that detects plasminogen activator inhibitor-1 (PAI-1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PAI-1 plays a crucial role in regulating fibrinolysis by inhibiting urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA), which are essential for the conversion of plasminogen to plasmin, a key enzyme in the breakdown of fibrin in blood clots. The regulation of these proteolytic activities is vital for maintaining hemostatic balance and preventing excessive bleeding or thrombosis. PAI-1 is predominantly secreted by endothelial cells and is found in both the extracellular matrix and circulation, where PAI-1 can influence various physiological and pathological processes, including wound healing, tissue remodeling, and cancer metastasis. Notably, PAI-1 exists in both active and latent forms, with the latent form being a stable, inactive state that can be converted back to its active form under certain conditions, highlighting the dynamic regulation of PAI-1 activity. Anti-PAI-1 antibody (3A120) is an invaluable tool for researchers studying the intricate mechanisms of fibrinolysis and its implications in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAI-1/SERPINE1 Antibody (3A120) | sc-59633 | 100 µg/ml | $316.00 |