PACRG Antibody (C-8): sc-373851
- PACRG Antibody (C-8) is a mouse monoclonal IgG1 κ PACRG antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-100 mapping near the N-terminus of PACRG of human origin
- PACRG Antibody (C-8) is recommended for detection of PACRG of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PACRG Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PACRG Antibody (C-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with PACRG Antibody (C-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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PACRG Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects PACRG protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PACRG (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PACRG protein, consisting of 257 amino acids, is involved in regulating the ubiquitin/proteasome system, which plays a crucial role in protein degradation and cellular homeostasis. This regulation helps maintain protein turnover balance, essential for cellular function and stress response. PACRG gene is located on chromosome 6q26 and is co-regulated with Parkin gene, sharing a common promoter region, suggesting a coordinated role in cellular processes. PACRG expression has been detected in various human tissues, except placenta, indicating widespread relevance in physiological and potentially pathological contexts. Research has identified significant associations between PACRG and leprosy susceptibility, highlighting a potential role in immune response mechanisms. Possession of specific risk alleles in the regulatory region shared with PARK2 has been shown to be predictive of leprosy, underscoring PACRG′s importance in disease susceptibility and potential as a biomarker for further studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PACRG Antibody (C-8) References:
- Identification of a novel gene linked to parkin via a bi-directional promoter. | West, AB., et al. 2003. J Mol Biol. 326: 11-9. PMID: 12547187
- Susceptibility to leprosy is associated with PARK2 and PACRG. | Mira, MT., et al. 2004. Nature. 427: 636-40. PMID: 14737177
- It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG). | Lockhart, PJ., et al. 2004. Mov Disord. 19: 101-4. PMID: 14743368
- Genetic dissection of immunity in leprosy. | Alcaïs, A., et al. 2005. Curr Opin Immunol. 17: 44-8. PMID: 15653309
- Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism. | Deng, H., et al. 2005. Neurosci Lett. 382: 297-9. PMID: 15925106
- Defining the breakpoints of the quaking(viable) mouse mutation reveals a duplication from a Parkin intron. | Dapper, JD. and Justice, MJ. 2005. Mov Disord. 20: 1369-74. PMID: 16001410
- The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis. | Dawe, HR., et al. 2005. J Cell Sci. 118: 5421-30. PMID: 16278296
- Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. | Malhotra, D., et al. 2006. Eur J Hum Genet. 14: 438-42. PMID: 16391553
- PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. | Ali, S., et al. 2006. Clin Exp Immunol. 144: 425-31. PMID: 16734611
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PACRG Antibody (C-8) | sc-373851 | 200 µg/ml | $322.00 | |||
PACRG Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-522530 | 200 µg Ab, 40 µg BP | $361.00 | |||
PACRG Antibody (C-8) AC | sc-373851 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PACRG Antibody (C-8) HRP | sc-373851 HRP | 200 µg/ml | $322.00 | |||
PACRG Antibody (C-8) FITC | sc-373851 FITC | 200 µg/ml | $336.00 | |||
PACRG Antibody (C-8) PE | sc-373851 PE | 200 µg/ml | $349.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 488 | sc-373851 AF488 | 200 µg/ml | $364.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 546 | sc-373851 AF546 | 200 µg/ml | $364.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 594 | sc-373851 AF594 | 200 µg/ml | $364.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 647 | sc-373851 AF647 | 200 µg/ml | $364.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 680 | sc-373851 AF680 | 200 µg/ml | $364.00 | |||
PACRG Antibody (C-8) Alexa Fluor® 790 | sc-373851 AF790 | 200 µg/ml | $364.00 |