p73 Antibody (5B429): sc-56191

p73 Antibody (5B429) is a mouse monoclonal IgG1 antibody designed to detect the full-length p73 protein, also known as TP73, across mouse, rat, and human species using western blotting (WB) and enzyme-linked immunosorbent assay (ELISA) applications. p73 (5B429) antibody targets epitopes present in the entire structure of the p73 protein, ensuring comprehensive recognition without cross-reactivity with the closely related p53 protein. p73 is a critical member of the p53 family of transcription factors, involved in regulating cell cycle progression, apoptosis, and genomic stability. Post-translational modifications of p73, such as phosphorylation, acetylation, and ubiquitination, play essential roles in modulating activity, stability, and interactions with other proteins, thereby influencing function in tumor suppression and cellular stress responses. Phosphorylation of p73 can enhance transcriptional activity, while ubiquitination typically targets p73 for proteasomal degradation, balancing levels within the cell. Understanding these modifications is crucial for elucidating p73′s role in cancer biology, as aberrant post-translational regulation can lead to impaired tumor suppressor functions and contribute to oncogenesis. anti-p73 antibody (5B429) enables researchers to study these critical modifications and their impact on p73 activity, facilitating advancements in cancer research and the development of targeted therapies. By providing reliable detection of full-length p73 and modified forms, p73 monoclonal antibody (5B429) supports the exploration of p73′s multifaceted roles in maintaining cellular homeostasis and preventing malignant transformation. Whether investigating the mechanisms of p73 regulation or assessing expression in various cancer models, p73 (5B429) antibody is an indispensable tool for comprehensive molecular analyses.

The preferred p73 antibody is p73 Antibody (E-4): sc-17823.