p73 Antibody (5B1288): sc-56190
- p73 Antibody (5B1288) is a mouse monoclonal IgG, cited in 1 publications, provided at 100 µg/ml
- raised against full length p73 of human origin
- recommended for detection of α, β, γ, and δ isoforms of full length p73 as well as the dominant negative full length p73 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with p53
- See p73 (E-4): sc-17823 for p73 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p73 Antibody (5B1288). This work is in progress.
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p73 Antibody (5B1288) is a mouse monoclonal IgG antibody engineered to recognize the full-length p73 protein, including its α, β, γ, and δ isoforms, as well as the dominant negative variants in human, mouse, and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Targeting the entire structure of the p73 protein, p73 monoclonal antibody (5B1288) binds to epitopes present in the full-length form, ensuring comprehensive detection without cross-reactivity with the closely related p53 protein. The p73 protein, also known as TP73, is a crucial member of the p53 family of transcription factors, characterized by a multi-domain architecture that includes a highly conserved DNA-binding domain, a transactivation domain, and an oligomerization domain. This structural complexity allows p73 to regulate diverse cellular processes such as apoptosis, cell cycle progression, and differentiation, making p73 integral to maintaining cellular homeostasis and preventing tumorigenesis. The ability of p73 to form tetramers through its oligomerization domain is essential for its function in binding DNA and activating target gene expression. Understanding the structural nuances of p73 is vital for elucidating its role in cancer biology, as different isoforms can have opposing effects on cell fate decisions. p73 monoclonal antibody (5B1288) provides researchers with a reliable tool to study the intricate structural and functional dynamics of p73 isoforms, facilitating advancements in cancer research and the development of targeted therapies. By enabling precise detection and analysis of p73 variants, anti-p73 antibody (5B1288) supports the exploration of p73′s multifaceted roles in tumor suppression and its interactions with other cellular proteins, thereby contributing to a deeper understanding of cancer mechanisms and potential therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p73 Antibody (5B1288) | sc-56190 | 100 µg/ml | $322.00 |